{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:01:30Z","timestamp":1784116890249,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the secondary attack rate (SAR) in children and adolescents, contacts of essential activities workers who were infected by SARS\u2010CoV\u20102; and to describe associated clinical and epidemiological data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study conducted in children and adolescents aged 5 to 19 years of age, that were household contacts of parents and other relatives who were infected by SARS\u2010CoV\u20102 in the city of Goi\u00e2nia, Central Brazil, from March to October 2020. Sociodemographic and clinical data were collected from all participants. Nasopharyngeal and oropharyngeal swabs were collected and tested for SARS\u2010CoV\u20102 RNA using real\u2010time reverse transcription polymerase chain reaction (RT\u2010PCR). Factors associated with SARS\u2010CoV\u20102 infection and SAR were analyzed using Poisson regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 267 children and adolescents were investigated. The prevalence of SARS\u2010CoV\u20102 RNA by the real\u2010time RT\u2010PCR test and\/or the presence of COVID\u201019 associated symptoms (anosmia\/ageusia and flu syndrome) was 25.1% (95.0% Confidence Interval [95.0% CI]\u2009=\u200920.3\u201030.6). More than half (55.1%) of the participants had sygns and symptoms. The most prevalent signs and symptoms in positive individuals were nasal congestion (62.7%), headache (55.2%), cough (50.8%), myalgia (47.8%), runny nose (47.8%), and anosmia (47.8%). The Poisson model showed that the following signs or symptoms were associated with SARS\u2010CoV\u20102 infection: fever, nasal congestion, decreased appetite, nausea, anosmia, and ageusia. Families that had more than one infected adult, in addition to the index case, presented greater transmissibility to children and adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results contribute to the hypothesis that children and adolescents are not important sources of transmission of SARS\u2010CoV\u20102 in the home environment during a period of social distancing and school closure; even though they are susceptible to infection in the household (around \u00bc of our study population).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25711","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T13:53:02Z","timestamp":1633009982000},"page":"162-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Secondary household transmission of SARS\u2010CoV\u20102 among children and adolescents: Clinical and epidemiological aspects"],"prefix":"10.1002","volume":"57","author":[{"given":"Eliane T.","family":"Afonso","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine, Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomar M.","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine, Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lusmaia D. C.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine, Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia M.","family":"Fortes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine, Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine, Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielli C.","family":"Bichuetti\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine, Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia D. A.","family":"Aredes","sequence":"additional","affiliation":[{"name":"Faculty of Nursing Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claci F. W.","family":"Rosso","sequence":"additional","affiliation":[{"name":"Faculty of Nursing Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa\u00e9tila dos S.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculty of Nursing Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fab\u00edola S.","family":"Fiaccadori","sequence":"additional","affiliation":[{"name":"Virology and Cell Culture Laboratory, Institute of Tropical Pathology and Public Health Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menira B. de L. D. e","family":"Souza","sequence":"additional","affiliation":[{"name":"Virology and Cell Culture Laboratory, Institute of Tropical Pathology and Public Health Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elis\u00e2ngela de P.","family":"Silveira\u2010Lacerda","sequence":"additional","affiliation":[{"name":"Department of Genetics, Institute of Biological Sciences Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela S.","family":"Bazilio","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Analysis of Higher Education, Institute of Biological Sciences Federal University of Goi\u00e1s  Goi\u00e2nia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9914-8771","authenticated-orcid":false,"given":"Clayton L.","family":"Borges","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Institute of Biological Sciences Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana A. P.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Institute of Biological Sciences Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra V.","family":"Naghettini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine, Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo S. 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