{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:37:27Z","timestamp":1768001847831,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperemesis gravidarum, a clinical entity characterized by severe nausea and excess vomiting, might lead to a suboptimal maternal nutritional status during pregnancy and subsequently to adverse respiratory health in the offspring. The role of common vomiting symptoms on offspring's respiratory health is unclear. We examined the associations of maternal daily vomiting during early pregnancy with childhood respiratory outcomes, and potential explaining factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was embedded in a population\u2010based prospective cohort study from early pregnancy onwards among 4232 mothers and their children. Maternal vomiting during early pregnancy was assessed by a questionnaire. At age 10 years, information on current wheezing and ever asthma was obtained by a questionnaire, and lung function was measured by spirometry at our research center. We used multiple regression analyses to assess the associations of maternal daily vomiting during early pregnancy with childhood respiratory outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to children from mothers without daily vomiting during early pregnancy, children from mothers with daily vomiting during early pregnancy had a higher forced expiratory flow when 75% of the forced vital capacity (FVC) is exhaled (Z\u2010score difference [95% confidence interval, CI]: 0.13 [0.03, 0.23]), and an increased risk of current wheezing and ever asthma ([odds ratio, OR] [95% CI]: 1.75 [1.10, 2.79] and 1.61 [1.13, 2.31], respectively). These associations were fully explained by sociodemographic factors, but not sex or lifestyle\u2010, infectious\u2010, or growth\u2010related factors. Maternal daily vomiting during early pregnancy was not associated with forced expiratory volume in 1\u2009s (FEV<jats:sub>1<\/jats:sub>), FVC, and FEV<jats:sub>1<\/jats:sub>\/FVC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Only sociodemographic factors explain the associations of maternal daily vomiting during early pregnancy with childhood respiratory outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25747","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T07:26:52Z","timestamp":1636097212000},"page":"367-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Influence of maternal vomiting during early pregnancy on school\u2010age respiratory health"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1413-0714","authenticated-orcid":false,"given":"Sunayna D.","family":"Poeran\u2010Bahadoer","sequence":"first","affiliation":[{"name":"The Generation R Study Group, Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0826-9931","authenticated-orcid":false,"given":"Evelien R.","family":"van Meel","sequence":"additional","affiliation":[{"name":"The Generation R Study Group, Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7967-4600","authenticated-orcid":false,"given":"Romy","family":"Gaillard","sequence":"additional","affiliation":[{"name":"The Generation R Study Group, Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Pediatrics, Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2939-0041","authenticated-orcid":false,"given":"Vincent W. 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