{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:14:47Z","timestamp":1791303287567,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A hallmark of many respiratory conditions is the presence of nocturnal symptoms. Nevertheless, especially in children there is currently still a huge diagnostic gap in detecting nighttime symptoms, which leads to an underestimation of the frequency in clinical practise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the clinical applicability and determined the formal test characteristics of the LEOSound \u00ae system, a device for digital long\u2010time recording and automated detection of acoustic airway events. Airway sounds were recorded overnight in 115 children and adolescents (1\u201317 years) with and without respiratory conditions. The automated classification for \u201ccough\u201d and \u201cwheezing\u201d was subsequently validated against the manual acoustic reassessment by an expert physician.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The general acceptance was good across all age groups and a technically successful recording was obtained in 98 children, corresponding to 92,976 sound epochs (\u00e0 30\u2009s) or a total of 774\u2009h of lung sounds. We found a sensitivity of 89% and a specificity of 99% for the automated detection of cough. For detection of wheezing, sensitivity and specificity were both 98%. The <jats:italic>cough index<\/jats:italic> and the <jats:italic>wheeze index<\/jats:italic> (events per hour) of individual patients showed a strong positive correlation (cough: <jats:italic>r<\/jats:italic><jats:sub>S<\/jats:sub>\u2009=\u20090.85, wheeze: <jats:italic>r<\/jats:italic><jats:sub>S<\/jats:sub>\u2009=\u20090.95) and a sufficient agreement of the two assessment methods in the Bland\u2013Altman analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data show that the LEOSound\u00ae is a suitable device for standardized detection of cough and wheezing and hence a promising diagnostic tool to detect nocturnal respiratory symptoms, especially in children. However, a validation process to reduce false positive classifications is essential in clinical routine use.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25768","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T14:37:25Z","timestamp":1637419045000},"page":"551-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Validation of the LEOSound\u00ae monitor for standardized detection of wheezing and cough in children"],"prefix":"10.1002","volume":"57","author":[{"given":"Christof","family":"Urban","sequence":"first","affiliation":[{"name":"Department of Pediatric Pneumology and Allergy University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg Regensburg Germany"},{"name":"Alpenklinik Santa Maria Bad Hindelang Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Allergy University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0674-3836","authenticated-orcid":false,"given":"Regina","family":"Conradt","sequence":"additional","affiliation":[{"name":"Division of Pneumology, Department of Internal Medicine, Intensive Care and Sleep Medicine Philipps\u2010University Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kabesch","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Allergy University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7684-4272","authenticated-orcid":false,"given":"Christiane","family":"Lex","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Intensive Care Medicine University Hospital Goettingen Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Zacharasiewicz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Wilhelminenspital Teaching Hospital of the University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1495-7279","authenticated-orcid":false,"given":"Sebastian","family":"Kerzel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Allergy University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg Regensburg 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