{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:49:08Z","timestamp":1762660148472,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate clinical applications of dual\u2010energy computed tomography (DECT) in pediatric\u2010specific lung diseases and compare ventilation and perfusion findings with those from single\u2010photon emission computed tomography (SPECT\u2010CT) V\/Q.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients at our institution who underwent exams using both techniques within a 3\u2010month period were included in this study. Two readers independently described findings for DECT, and two other readers independently analyzed the SPECT\u2010CT V\/Q scan data. All findings were compared between readers and disagreements were reassessed and resolved by consensus. Inter\u2010modality agreements are described throughout this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight patients were included for evaluation. The median age for DECT scanning was 3.5\u2009months (IQR\u2009=\u20092). Five of these patients were scanned for both DECT and SPECT\u2010CT V\/Q studies the same day, and three had a time gap of 7, 65, and 94\u2009days between studies. The most common indications were chronic lung disease (5\/8; 63%) and pulmonary hypertension (6\/8; 75%). DECT and SPECT\u2010CT V\/Q identified perfusion abnormalities in concordant lobes in most patients (7\/8; 88%). In one case, atelectasis limited DECT perfusion assessment. Three patients ultimately underwent lobectomy with corresponding perfusion abnormalities identified by all reviewers on both DECT and SPECT\u2010CT V\/Q in all resected lobes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DECT is a feasible technique that could be considered as an alternative for SPECT\u2010CT V\/Q for lung perfusion evaluation in infants.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25788","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T13:32:10Z","timestamp":1639661530000},"page":"702-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pilot study for comparative assessment of dual\u2010energy computed tomography and single\u2010photon emission computed tomography V\/Q scanning for lung perfusion evaluation in infants"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5613-162X","authenticated-orcid":false,"given":"Karen I.","family":"Ramirez\u2010Suarez","sequence":"first","affiliation":[{"name":"Department of Radiology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian A.","family":"Barrera","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4626-0732","authenticated-orcid":false,"given":"Hansel J.","family":"Otero","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Biko","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa J.","family":"States","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabah","family":"Servaes","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Department of Radiology West Virginia University Medicine Children's Hospital Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0691-3551","authenticated-orcid":false,"given":"Joseph","family":"Piccione","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia University of Pennsylvania School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5956-1975","authenticated-orcid":false,"given":"Jordan B.","family":"Rapp","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.124602"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2017.02.006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.13869"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22751"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2016150081"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.02.043"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2015.05.023"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5467-2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-012-2465-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sult.2020.05.008"},{"key":"e_1_2_10_12_1","first-page":"16","article-title":"The measure, reporting and management of radiation dose in CT. College Park MD 20740\u20103846","volume":"96","author":"Chairperson CM","year":"2008","journal-title":"AAPM Report"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0146645314558019"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-013-2975-y"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2020.02.006"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.9112"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/RTI.0000000000000061"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12112789"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-016-3668-x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2015.11.035"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2018.05.07"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-010-1759-7"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-010-1645-3"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002470050058"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20466"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.04.033"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.08.020"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.15994"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2018.10.006"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.25788","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T11:20:54Z","timestamp":1693135254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.25788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,27]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/ppul.25788"],"URL":"https:\/\/doi.org\/10.1002\/ppul.25788","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"type":"print","value":"8755-6863"},{"type":"electronic","value":"1099-0496"}],"subject":[],"published":{"date-parts":[[2021,12,27]]},"assertion":[{"value":"2021-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}