{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:34:26Z","timestamp":1776274466419,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The heterogeneity of bronchiolitis may imply or reflect a different predisposition to respiratory sequelae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our aim was to investigate whether, among infants hospitalized with bronchiolitis, different clinical profiles extracted by latent class analysis (LCA) are associated with different risks of wheezing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Over 15 consecutive epidemic seasons (2004\u20132019), we prospectively enrolled infants &lt;1 year hospitalized for the first episode of bronchiolitis in a single tertiary hospital. A detailed clinical questionnaire was filled for each infant. LCA was applied to differentiate bronchiolitis phenotypes, and after hospital discharge, a phone interview was performed annually to record the presence of wheezing episodes. Adjusted multivariate regression analyses were run to investigate the risk of wheezing during 7 years follow\u2010up according to clinical phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LCA performed on 1312 infants resulted in a three\u2010class model. Profile 1 (65.5%): moderate bronchiolitis; Profile 2 (6.1%): severe bronchiolitis; and Profile 3(28.4%): bronchiolitis infants with high eosinophils blood count. At 1 year of follow up, about 50% of children presented wheezing in each profile. Compared to Profile 1, the adjusted odds ratio (OR) of having wheezing episodes was significantly higher in Profile 2 at 2, 3, and 4 years of follow\u2010up. At 7 years, Profile 3 had an adjusted OR\u2009=\u20092.58, higher than Profile 2 (adjusted OR\u2009=\u20092.29).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LCA clearly identified a \u201cmoderate\u201d, \u201csevere,\u201d and \u201chigh eosinophils blood count\u201d bronchiolitis. During the first 4 years after bronchiolitis, the \u201csevere\u201d profile showed the higher risk of wheezing, but after 7 years this risk seems higher in the \u201chigh eosinophils blood count\u201d group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25799","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T09:32:16Z","timestamp":1640079136000},"page":"616-622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Bronchiolitis phenotypes identified by latent class analysis may influence the occurrence of respiratory sequelae"],"prefix":"10.1002","volume":"57","author":[{"given":"Laura","family":"Petrarca","sequence":"first","affiliation":[{"name":"Department of Maternal, Infantile, and Urological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8880-3462","authenticated-orcid":false,"given":"Raffaella","family":"Nenna","sequence":"additional","affiliation":[{"name":"Department of Maternal, Infantile, and Urological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greta","family":"Di Mattia","sequence":"additional","affiliation":[{"name":"Department of Maternal, Infantile, and Urological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Frassanito","sequence":"additional","affiliation":[{"name":"Department of Maternal, Infantile, and Urological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-4281","authenticated-orcid":false,"given":"Jose A.","family":"Castro\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Pediatric Pulmonology School of Medicine, Pontificia Universidad Catolica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.","family":"Rodriguez Martinez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine, Universidad Nacional de Colombia  Bogota Colombia"},{"name":"Department of Pediatric Pulmonology and Pediatric Critical Care Medicine School of Medicine, Universidad El Bosque  Bogota Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrica","family":"Mancino","sequence":"additional","affiliation":[{"name":"Department of Maternal, Infantile, and Urological Sciences \u201cSapienza\u201d University of Rome  Rome 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