{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:13:37Z","timestamp":1771046017288,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR003017"],"award-info":[{"award-number":["UL1TR003017"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To report on the clinical, laboratory, and radiological findings of adolescents who presented during the SARS\u2010CoV\u20102 surge with symptoms of Coronavirus disease 2019 (COVID\u201019), did not test positive for the infection, and were diagnosed with E\u2010cigarette and vaping product use associated lung injury (EVALI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of 12 cases of EVALI admitted to the Bristol Meyers Squibb Children's Hospital between February 2020 and June 2020 was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ages of the patients ranged from 14 to 19 years. There were six\u00a0males and six\u00a0females. Three patients had a past history of anxiety, depression, or other psychiatric\/mental health disorder, 9\u00a0had prolonged coagulation profile (prothrombin time, partial thromboplastin time,\u00a0and\/or International Normalized Ratio), and 11\u00a0had elevated inflammatory markers. Eight needed respiratory support. All 12 were negative for SARS\u2010CoV\u20102 PCR. Four were tested for IgG antibodies and were negative. As these cases were admitted to rule out COVID infection, initial treatment included hydroxychloroquine. Steroids were started only after SARS\u2010CoV\u20102 PCR was shown to be negative. Urine tetrahydrocannabinol was positive in all cases. Chest X\u2010ray\u00a0and computed tomography\u00a0findings showed ground glass opacities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinical and radiological features are similar in both EVALI and SARS\u2010CoV\u20102 infection. Inflammatory markers are elevated in both conditions. A detailed social and substance use history in patients presenting with \u201ctypical\u201d COVID pneumonia like illness is important. EVALI should be ruled in early to start the appropriate treatment. Given the ongoing pandemic, pediatricians and other health\u2010care providers need to be aware of other conditions that can masquerade as SARS\u2010CoV\u20102.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25804","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T11:36:57Z","timestamp":1640777817000},"page":"623-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["E\u2010cigarette or vaping product use associated lung injury (EVALI) in the time of COVID\u201019: A clinical dilemma"],"prefix":"10.1002","volume":"57","author":[{"given":"Daniel","family":"Helfgott","sequence":"first","affiliation":[{"name":"Department of Pediatrics Rutgers\u2010Robert Wood Johnson Medical School New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle","family":"Capozzoli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Rutgers\u2010Robert Wood Johnson Medical School New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovanna","family":"Madray","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Rutgers\u2010Robert Wood Johnson Medical School New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha","family":"Baig","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0Division of Pulmonology and Cystic Fibrosis Center Rutgers\u2010Robert Wood Johnson Medical School New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Uppaluri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0Division of Pulmonology and Cystic Fibrosis Center Rutgers\u2010Robert Wood Johnson Medical School New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunanda","family":"Gaur","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Allergy and Immunology, Department of Pediatrics Rutgers\u2010Robert Wood Johnson Medical School New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Radiology Rutgers\u2010Robert Wood Johnson Medical School New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Amorosa","sequence":"additional","affiliation":[{"name":"Department of Radiology Rutgers\u2010Robert Wood Johnson Medical School New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3854-9915","authenticated-orcid":false,"given":"Maya","family":"Ramagopal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0Division of Pulmonology and Cystic Fibrosis Center Rutgers\u2010Robert Wood Johnson Medical School New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6514a1"},{"key":"e_1_2_8_3_1","article-title":"Toxicity of JUUL fluids and aerosols correlates strongly with nicotine and some flavor chemical concentrations","author":"Omaiye EE","year":"2018","journal-title":"BioRxiv"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30415-1"},{"key":"e_1_2_8_5_1","unstructured":"Outbreak of Lung Injury Associated with E\u2010Cigarette Use or Vaping. 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