{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:43:05Z","timestamp":1774928585317,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Noninvasive markers more accurate than FiO<jats:sub>2<\/jats:sub> would be useful to assess the severity of RDS and guide its treatment. Our aim was to assess for the first time the possibility of continuously monitoring lung oxygenation (rSO<jats:sub>2<\/jats:sub>L) by near\u2010infrared spectroscopy (NIRS) and to evaluate whether rSO<jats:sub>2<\/jats:sub>L correlates with other oxygenation indices and RDS severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We carried out this proof\u2010of\u2010concept study on 20 preterm infants with RDS requiring noninvasive respiratory support. Patients were continuously studied for 24\u2009h by NIRS and rSO<jats:sub>2<\/jats:sub>L was correlated with SpO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio, a\/APO<jats:sub>2<\/jats:sub>, and O.I.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall value of rSO<jats:sub>2<\/jats:sub>L was 80.1\u2009\u00b1\u20096.2%, without significant differences between the right and left hemithorax (80.2\u2009\u00b1\u20096.7 vs. 80.0\u2009\u00b1\u20095.7%; <jats:italic>p<\/jats:italic>\u2009=\u20090.869). Mean values of total, right, and left rSO<jats:sub>2<\/jats:sub>L did not significantly change during the 24\u2010h study period. Linear regression analysis demonstrated a significant positive relationship between total rSO<jats:sub>2<\/jats:sub>L and SpO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and a\/APO<jats:sub>2<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009=\u20090.040), and a negative relationship between total rSO<jats:sub>2<\/jats:sub>L and O.I. (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.309; <jats:italic>p<\/jats:italic>\u2009=\u20090.022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Continuous monitoring of rSO<jats:sub>2<\/jats:sub>L by NIRS in preterm infants with RDS is feasible and safe. The correlation of rSO<jats:sub>2<\/jats:sub>L with other indices of oxygenation and RDS severity supports the accuracy and reliability of this measurement.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25824","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T04:17:18Z","timestamp":1641961038000},"page":"2306-2312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Measurement\u00a0of lung oxygenation\u00a0by near\u2010infrared spectroscopy in preterm\u00a0infants with respiratory distress syndrome: A proof\u2010of\u2010concept study"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1639-621X","authenticated-orcid":false,"given":"Carlo","family":"Dani","sequence":"first","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"},{"name":"Department of Neurosciences,\u00a0Psychology, Drug Research and Child Health Careggi University Hospital of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Ciarci\u00e0","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Miselli","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Luzzati","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Petrolini","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3146-1446","authenticated-orcid":false,"given":"Iuri","family":"Corsini","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratesi","family":"Simone","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.05.054"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499361"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10244"},{"key":"e_1_2_9_5_1","article-title":"Prophylactic versus selective use of surfactant in 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