{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:39:55Z","timestamp":1791038395313,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify the predictors of successful first trial off nasal continuous positive airway pressure (nCPAP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of infants \u226429 weeks\u2019 gestation who required nCPAP for &gt;24\u2009h was conducted. Logistic regression was used to detect predictors for successful trial off nCPAP. Statistical analysis was performed using the SAS software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 727 infants were included in the analysis. Infants who were successful in their first trial off nCPAP (<jats:italic>n<\/jats:italic>\u2009=\u2009313) were of higher gestational age (GA) and birth weight (BW), as well as a higher proportion of female infants, compared with those who were not successful (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). When stratified by GA, a negative correlation was noted between GA and postmenstrual age at successful trial off nCPAP or high flow nasal cannula (HFNC) (<jats:italic>r<\/jats:italic>\u2009=\u20090.45, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Logistic regression analysis showed that GA (odds ratio [OR] 1.13, 95% confidence interval [CI] [1.03\u20131.24], <jats:italic>p<\/jats:italic>\u2009=\u20090.01) and percentage of time spent with an oxygen saturation over 89% in the 24\u2009h preceding the trial off nCPAP (OR 1.08, 95% CI [1.05\u20131.11], <jats:italic>p<\/jats:italic>\u2009=\u20090.00) were independent predictors for successful trial off nCPAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Successful trial off\u00a0nCPAP or HFNC in preterm infants is significantly associated with higher GA, BW, female gender, and the specific oxygen saturation histogram in the preceding 24\u2010h\u00a0period.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25827","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T08:03:55Z","timestamp":1642233835000},"page":"1000-1007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictors of successful trial off continuous positive airway pressure and high flow nasal cannula in preterm infants &lt;30 weeks' gestation: A retrospective study"],"prefix":"10.1002","volume":"57","author":[{"given":"Nada","family":"Mohsen","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Toronto  Toronto Ontario Canada"},{"name":"Department of Pediatrics Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"Department of Pediatrics Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehad","family":"Nasef","sequence":"additional","affiliation":[{"name":"Department of 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