{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:53:26Z","timestamp":1791806006260,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Understanding the impact of scoliosis surgery on lung function is important for counseling patients about risks and benefits of surgery. We prospectively compared the trends in lung function test (LFT) results before and after scoliosis surgery in children with neuromuscular diseases or dysmorphic syndromes. We hypothesized a stabilization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively included children with neuromuscular or syndromic scoliosis able to perform LFTs. We studied (forced) vital capacity ([F]VC), ratio of forced expiratory volume in 1\u2009s (FEV<jats:sub>1<\/jats:sub>) and FVC, and peak expiratory flow (PEF). Preoperative LFT results were compared with results 3\u20134 months after surgery. The mean monthly change in LFT results up to 2 years after surgery was compared with the preoperative natural history using linear mixed\u2010effects models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 43 patients. No significant change was observed in absolute values of (F)VC, FEV<jats:sub>1<\/jats:sub>\/FVC, and PEF before and after surgery. In 23 neuromuscular patients median standardized VC, FVC, and PEF decreased significantly after surgery from 43% to 33%, 42% to 31%, and 51% to 40%, respectively. In 20 syndromic patients, median FVC decreased from 68% to 65%. The monthly rate of change in FVC did not change significantly in both groups with a mean difference of 0.18% (95% CI: \u22120.27, \u22120.61) and \u22120.44% (95% CI: \u22121.05, 0.16).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No stabilization of lung function 3\u20134 months after scoliosis surgery was observed in children with neuromuscular and syndromic scoliosis with restrictive lung function disease. The effect on the rate of lung function decline remains inconclusive.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25857","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T08:20:09Z","timestamp":1645086009000},"page":"1303-1309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Short\u2010term effect and effect on rate of lung function decline after surgery for neuromuscular or syndromic scoliosis"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2918-9989","authenticated-orcid":false,"given":"Esther S.","family":"Veldhoen","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit, Wilhelmina Children's Hospital University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneloes","family":"de Vries","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Wilhelmina Children's Hospital University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1517-5914","authenticated-orcid":false,"given":"Tom P. C.","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5983-5251","authenticated-orcid":false,"given":"Moyo C.","family":"Kruyt","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7132-5967","authenticated-orcid":false,"given":"Ruben P. A.","family":"van Eijk","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brain Centre Rudolf Magnus University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Biostatistics &amp; Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce M.","family":"Tersmette","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Wilhelmina Children's Hospital University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3149-3998","authenticated-orcid":false,"given":"Erik H.","family":"Hulzebos","sequence":"additional","affiliation":[{"name":"Child Development and Exercise Center, Wilhelmina Children's Hospital University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8970-2740","authenticated-orcid":false,"given":"Ludo W.","family":"van der Pol","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brain Centre Rudolf Magnus University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2469-2131","authenticated-orcid":false,"given":"Roelie M.","family":"W\u00f6sten\u2010van Asperen","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Wilhelmina Children's Hospital University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2501-4121","authenticated-orcid":false,"given":"Cornelis K.","family":"van der Ent","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Wilhelmina Children's Hospital University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0000000000000396"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24664"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2017-000264"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20291"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.43.8.657"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01367-y"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000000383"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000255062.94744.52"},{"key":"e_1_2_10_13_1","first-page":"CD005375","article-title":"Surgery for scoliosis in Duchenne muscular dystrophy","volume":"10","author":"Cheuk DKL","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2003.00266.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-012-2585-4"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00301032"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000238659.12918.b5"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0000000000000078"},{"issue":"5","key":"e_1_2_10_19_1","first-page":"787","article-title":"Perioperative evaluation of respiratory muscle strength after scoliosis correction in patients with Duchenne muscular dystrophy. 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