{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:01:03Z","timestamp":1768971663302,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The SFR (SpO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio) offers a continuous, noninvasive reflection of pulmonary function regardless of whether the baby is ventilated or breathing spontaneously. We hypothesized that significant patent ductus arteriosus (PDA) shunting would impair pulmonary oxygen diffusion, reflected by decreased SFR; and that early PDA related decreases in SFR predict subsequent chronic lung disease (CLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively examined records from preterm neonates \u226430 weeks gestational age. Ductal shunting was graded for severity by first week echocardiogram. SFR was calculated as SpO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> and recorded on Day 7 of life and 36 weeks postmenstrual age (PMA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 104 infants: 65 with closed duct,\u00a017 with hemodynamically insignificant PDA, and 22 with hemodynamically significant (hsPDAs). CLD developed in 9 (14%) of those with closed ducts; 6 (35%) of those with hisPDA; and in 12 (55%) of those with hsPDA (<jats:italic>p<\/jats:italic>\u2009=\u20090.005). SFR values at 1 week postnatally were decreased in those with hsPDA and with hisPDA as compared with those with closed ducts\u00a0(closed ducts 452 [448\u2212457]\u00a0vs.\u00a0hisPDA 396 [294\u2212442]\u00a0vs.\u00a0hsPDA 327 [235\u2212369]; <jats:italic>p<\/jats:italic>\u2009=\u20090.00001). However, at 36 weeks only SFRs of babies with hsPDA remained significantly lower (467 [461\u2212467]\u00a0vs.\u00a0467 [413\u2212471]\u00a0vs.\u00a0369 [262\u2212436]\u00a0for closed vs.\u00a0hisPDA vs.\u00a0hsPDA respectively; <jats:italic>p<\/jats:italic>\u2009=\u20090.000148). Using ROC curve analysis, Week 1 SFR was strongly associated with hsPDA (area under curve [AUC]\u2009=\u20090.770; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and highly predictive (AUC\u2009=\u20090.801; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) of CLD at 36 weeks PMA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early decreases in SFR reflect both the acute and chronic pulmonary impact of PDA shunting, possibly providing the missing link supporting an association between hemodynamically significant PDA and subsequent CLD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25880","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T07:41:15Z","timestamp":1646379675000},"page":"1209-1213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A simple noninvasive biomarker can reflect both the acute and chronic pulmonary impact of patent ductus arteriosus\u00a0shunting"],"prefix":"10.1002","volume":"57","author":[{"given":"Alona","family":"Bin\u2010Nun","sequence":"first","affiliation":[{"name":"Department of Neonatology Shaare Zedek Medical Center Jerusalem Israel"},{"name":"Faculty of Medicine of the Hebrew University Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Shchors","sequence":"additional","affiliation":[{"name":"Department of Neonatology Shaare Zedek Medical Center Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rawan","family":"Abu\u2010Omar","sequence":"additional","affiliation":[{"name":"Department of Neonatology Shaare Zedek Medical Center Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yair","family":"Kasirer","sequence":"additional","affiliation":[{"name":"Department of Neonatology Shaare Zedek Medical Center Jerusalem Israel"},{"name":"Faculty of Medicine of the Hebrew University Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Mimouni","sequence":"additional","affiliation":[{"name":"Department of Neonatology Shaare Zedek Medical Center Jerusalem Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2248-1717","authenticated-orcid":false,"given":"Cathy","family":"Hammerman","sequence":"additional","affiliation":[{"name":"Department of Neonatology Shaare Zedek Medical Center Jerusalem Israel"},{"name":"Faculty of Medicine of the Hebrew University Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24265"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2013.04.005"},{"issue":"542","key":"e_1_2_9_4_1","first-page":"e9","article-title":"Pulse oximetry saturation to fraction inspired oxygen ratio as a measure of hypoxia under general anesthesia and the influence of positive end\u2010expiratory pressure","volume":"25","author":"Tripathi RS","year":"2010","journal-title":"J Crit Care"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01455-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.3.7509706"},{"issue":"538","key":"e_1_2_9_7_1","first-page":"e1","article-title":"Correlation of oxygen saturation as measured by pulse oximetry\/fraction of inspired oxygen ratio with PaO2\/fraction of inspired oxygen ratio in a heterogeneous sample of critically ill children","volume":"28","author":"Lobete C","year":"2013","journal-title":"J Crit Care"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2018.03.004"},{"issue":"4","key":"e_1_2_9_9_1","first-page":"212","article-title":"PDA: does it matter? Erratum in","volume":"7","author":"Abu\u2010Shaweesh JM","year":"2020","journal-title":"Int J Pediatr Adolesc Med"},{"issue":"20","key":"e_1_2_9_10_1","first-page":"31180","article-title":"Prolonged tracheal intubation and the association between patent ductus arteriosus and bronchopulmonary dysplasia: a secondary analysis of the PDA\u2010TOLERATE trial","volume":"0022","author":"Clyman RI","year":"2020","journal-title":"J Pediatr"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1605576"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_9_13_1","first-page":"216","article-title":"Relationship between duration of infant exposure to a moderate\u2010to\u2010large patent ductus arteriosus shunt and the risk of developing bronchopulmonary dysplasia or death before 36 weeks","volume":"37","author":"Clyman RI","year":"2019","journal-title":"Am J Perinatol"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.09.028"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-012-1851-0"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70172-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2012.41"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-303816"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.25880","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T07:17:26Z","timestamp":1692688646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.25880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,23]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/ppul.25880"],"URL":"https:\/\/doi.org\/10.1002\/ppul.25880","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,23]]},"assertion":[{"value":"2021-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}