{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T22:29:46Z","timestamp":1776810586121,"version":"3.51.2"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The largest age group among children and adolescents referred for lung transplantation for cystic fibrosis (CF) have been those in the pubertal or postpubertal age range. However, over 100 younger patients with CF have undergone lung transplantation over the last three decades in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of our experience with 18 children with CF who underwent lung transplantation in our center before the age of 11 years and compared them to our older CF lung transplant recipients and our larger CF Center population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The transplant population was demographically distinct from our CF center in terms of ethnicity, country of origin, and insurance status. Other notable findings were a high prevalence of methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic>, a high prevalence of CF\u2010related diabetes mellitus, and a high prevalence of consolidated lobar or whole lung disease. Posttransplant outcomes were comparable to those older than 10 years of age in our center until 5 years after transplant after which the younger cohort showed a superior enduring survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In an era of increasingly effective medications modifying the natural history of CF, identification of risk factors for early severe lung disease in CF remains relevant to permit interventions to prevent or postpone the time of future lung transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25882","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T06:11:50Z","timestamp":1646374310000},"page":"1513-1519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cystic fibrosis lung transplant recipients 10 years of age or younger: Predisposing factors for end\u2010stage disease"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5696-7112","authenticated-orcid":false,"given":"Ernestina","family":"Melicoff","sequence":"first","affiliation":[{"name":"Section of Pediatric Pulmonology, Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadel E.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Section of Pediatric Pulmonology, Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Hosek","sequence":"additional","affiliation":[{"name":"Department of Quality Assurance Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George B.","family":"Mallory","sequence":"additional","affiliation":[{"name":"Section of Pediatric Pulmonology, Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2017.11.019"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00119714"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-0636"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.08.012"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00109-2017"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2018.01.006"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201608-615OC"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908639"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.08.003"},{"key":"e_1_2_11_11_1","unstructured":"Cystic Fibrosis Center Report Texas Children's Hospital.https:\/\/www.cff.org"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.03.002"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02157-12"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24126"},{"key":"e_1_2_11_15_1","first-page":"821","article-title":"Treatment and prognosis of lobar and segmental atelectasis in cystic fibrosis","volume":"118","author":"Stern RC","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(83)80028-1"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1258\/jrsm.2012.12s009"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.04.015"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0586"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202008-933OC"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2011.08.006"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23715"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16f06.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2015.09.008"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1768"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204303261804"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70442-1"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32834ba899"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2730"},{"key":"e_1_2_11_30_1","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1002\/ppul.24434","article-title":"The demographics of adverse outcomes in cystic fibrosis","volume":"54","author":"McGarry ME","year":"2019","journal-title":"Pediatr Pulmonol"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24377"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2020.10.002"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1546291"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxh001"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.09.006"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13018"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13188"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25882","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.25882","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T16:19:36Z","timestamp":1692980376000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.25882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,14]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1002\/ppul.25882"],"URL":"https:\/\/doi.org\/10.1002\/ppul.25882","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,14]]},"assertion":[{"value":"2021-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}