{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T18:51:45Z","timestamp":1784314305451,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL149693"],"award-info":[{"award-number":["HL149693"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with severe asthma have substantial morbidity and healthcare utilization. Pediatric severe asthma is a heterogeneous disease, and a multidisciplinary approach can improve the diagnosis and management of these children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the electronic health records for patients seen in the Severe Asthma Clinic (SAC) at UPMC Children's Hospital of Pittsburgh between August 2012 and October 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 110 patients in whom we extracted data, 46% were female, 48% were Black\/African American, and 41% had \u22651 admission to the pediatric intensive care unit (PICU) for asthma. Compared to patients without a PICU admission, those with \u22651 PICU admission were more likely to be non\u2010White (64.4% vs. 41.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.031) and more atopic (eosinophil count geometric mean\u2009=\u2009673 vs. 319 cells\/mm<jats:sup>3<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.002; total IgE geometric mean\u2009=\u2009754 vs. 303 KU\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), and to have lower pre\u2010bronchodilator FEV1 (58.6% [\u00b118.1%] vs. 69.9% [\u00b118.7%], <jats:italic>p<\/jats:italic>\u2009=\u20090.002) and elevated FeNO (60% vs. 22%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). In this cohort, 84% of patients were prescribed high\u2010dose ICS\/LABA and 36% were on biologics. Following enrollment in the SAC, severe exacerbations decreased from 3.2\/year to 2.2\/year (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001); compared to the year before joining the SAC, in the following year the group had 106 fewer severe exacerbations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This large cohort of children with severe asthma had a high level of morbidity and healthcare utilization. Patients with a history of PICU admissions for asthma were more likely to be nonwhite and highly atopic, and to have lower lung function. Our data support a positive impact of a multidisciplinary clinic on patients with severe childhood asthma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25887","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T09:08:20Z","timestamp":1646816900000},"page":"1447-1455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Severe asthma in children: Description of a large multidisciplinary clinical cohort"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8357-6181","authenticated-orcid":false,"given":"Maria","family":"Forero Molina","sequence":"first","affiliation":[{"name":"Divisions of Allergy and Immunology UPMC Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"Division of Pediatric Pulmonary Medicine UPMC Children's Hospital of Pittsburgh Pittsburgh Pennsylvania 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