{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T21:24:41Z","timestamp":1781299481989,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine objective daytime predictors of nocturnal hypercapnic hypoventilation (NHH) and identify a forced vital capacity (FVC) z\u2010score cut off that predicts NHH using the 2012 Global Lung Function Initiative (GLI) reference equations in pediatric neuromuscular patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Single\u2010centre retrospective medical record review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary pediatric hospital in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Children (&lt;18 years old) with a neuromuscular disorder (NMD) who had a diagnostic sleep study over a 5\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty children were included, median age 11.9 years (interquartile range [IQR]: 4.5\u201314.3). The majority of children had a diagnosis of Duchenne Muscular Dystrophy (32%). NHH was diagnosed in 18 children (36%). Multivariate logistic regression analysis performed for the entire cohort confirmed a statistically significant association between NHH and scoliosis (odds ratio [OR]: 3.3, <jats:italic>p<\/jats:italic>\u2009=\u20090.03), but not age (OR: 1.01, <jats:italic>p<\/jats:italic>\u2009=\u20090.26), body mass index z\u2010score (OR: 0.86, <jats:italic>p<\/jats:italic>\u2009=\u20090.26) or use of a wheelchair for mobility (OR: 1.25, <jats:italic>p<\/jats:italic>\u2009=\u20090.72). For the subset of 29 children who had spirometry testing (median age 12.9 years [IQR: 10.2\u201314.3]), FVC z\u2010score was the only statistically significant predictor of NHH (OR: 0.45, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). NHH was predicted by an FVC z\u2010score &lt;\u22123.24 (sensitivity 78%, specificity 73%), or FVC &lt;60% predicted (sensitivity 78%, specificity 73%). There was a strong positive correlation between FVC and forced expiratory volume in 1\u2009s z\u2010scores (r<jats:sub>p<\/jats:sub>\u2009=\u20090.98, <jats:italic>p<\/jats:italic>\u2009=\u20090.00) and FVC and peak expiratory flow\u00a0 z\u2010scores (r<jats:sub>p<\/jats:sub>\u2009=\u20090.72, <jats:italic>p<\/jats:italic>\u2009=\u20090.00).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children with a NMD and scoliosis or a lower FVC z\u2010score have increased odds of having NHH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25890","type":"journal-article","created":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T11:08:35Z","timestamp":1647083315000},"page":"1497-1504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Daytime predictors of nocturnal hypercapnic hypoventilation in children with neuromuscular disorders"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1899-3392","authenticated-orcid":false,"given":"Megan","family":"Frohlich","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Sydney Children's Hospital  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Widger","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sydney Children's Hospital  Randwick New South Wales Australia"},{"name":"School of Women's and Children's Health UNSW Sydney  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Thambipillay","sequence":"additional","affiliation":[{"name":"Department of Sleep Medicine Sydney Children's Hospital  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Teng","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health UNSW Sydney  Randwick New South Wales Australia"},{"name":"Department of Sleep Medicine Sydney Children's Hospital  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Farrar","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health UNSW Sydney  Randwick New South Wales Australia"},{"name":"Department of Neurology Sydney Children's Hospital  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sydney Children's Hospital  Randwick New South Wales Australia"},{"name":"School of Women's and Children's Health UNSW Sydney  Randwick New South Wales 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