{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:41:16Z","timestamp":1790106076839,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bronchiolitis is the most frequent cause of hospitalization in infants younger than 1 year of age. We sought to evaluate the correlation between lymphocyte count and clinical manifestation in infants hospitalized with bronchiolitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We performed a retrospective cohort study evaluating 1297 children hospitalized for bronchiolitis from 2004 to 2019. A nasal washing was tested for 14 respiratory viruses by PCR. A clinical severity score, ranging 0\u20138, was assigned at hospital admission. History and clinical course were recorded for each infant. Patients were divided in 3 groups according to lymphocyte count tertiles. Parents of enrolled patients have been phoned annually over 5 years to evaluate respiratory sequelae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 433 children had 2914.2\u2009\u00b1\u2009745.5\/mm<jats:sup>3<\/jats:sup> lymphocytes (Group 1), 432 had 4897.6\u2009\u00b1\u2009561.5\/mm<jats:sup>3<\/jats:sup> lymphocytes (Group 2) and 432 had 7884\u2009\u00b1\u20091903.3\/mm<jats:sup>3<\/jats:sup> lymphocytes (Group 3). Group 1 patients were more frequently infected by RSV and presented with fever, a worse clinical severity score. They more frequently needed oxygen supplementation, underwent a prolonged hospitalization needed to be admitted to pediatric intensive care unit. Finally, they had more frequently a family history of eczema, wheezing and asthma. We found no differences between lymphocytes count and respiratory sequelae (at least two episodes of wheezing per year).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Infants with low lymphocyte count are more likely to have a worse clinical course of bronchiolitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25919","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T05:39:26Z","timestamp":1649741966000},"page":"1770-1775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Low lymphocyte count: A clinical severity marker in infants with bronchiolitis"],"prefix":"10.1002","volume":"57","author":[{"given":"Luigi","family":"Matera","sequence":"first","affiliation":[{"name":"Department of Maternal, Infantile and Urological Sciences Sapienza University of Rome Rome 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