{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:12:24Z","timestamp":1788779544978,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To describe the incidence, clinical features, outcomes, and mortality risk factors of sepsis associated with acute respiratory distress syndrome (ARDS) in pediatric patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were included in the study if they met the 2005 version of the International Pediatric Sepsis Consensus Conference and met the Pediatric Acute Lung Injury Consensus Conference (PALICC) definition within 48\u2009h of sepsis diagnosis. Patients were classified as mild, moderate, and severe by the worst oxygenation index (OI) within 72\u2009h of sepsis\u2010related ARDS diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between January 1, 2015 and March 13, 2020, 9836 patients were admitted to the pediatric intensive care unit\u00a0(PICU) of the Children's Hospital of Chongqing Medical University and 828 (8.4%) were identified with sepsis and 203 (24.5%) met the PALICC definition with a PICU mortality rate of 24.6% (50\/203) and a 90\u2010day mortality rate of 40.9% (83\/203). After adjusting for septic shock, the pediatric logistic organ dysfunction 2 (PELOD\u20102), high\u2010frequency oscillation ventilation (HFOV), and continuous renal replacement therapy (CRRT), the variables that retained an independent association with increased 90\u2010day mortality in pediatric sepsis\u2010related ARDS included ARDS severity, the pediatric risk of mortality III (PRISM III), number of organ dysfunctions and use of vasoactive drug types during PICU stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PICU mortality in pediatric sepsis\u2010related ARDS was high (24.6%) and severity of hypoxemia based on the worst OI value 72\u2009h after meeting the PALICC definition accurately stratified the patient outcomes. ARDS severity, PRISM III score, comorbid multiorgan dysfunction, and use of multiple vasoactive drugs during PICU stay were independent risk factors for 90\u2010day mortality in pediatric sepsis\u2010related ARDS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25943","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T01:51:16Z","timestamp":1651024276000},"page":"2003-2011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A single\u2010center PICU present status survey of pediatric sepsis\u2010related acute respiratory distress syndrome"],"prefix":"10.1002","volume":"57","author":[{"given":"Liang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Emergency Children's Hospital of Chongqing Medical University Chongqing China"},{"name":"National Clinical Research Center for Child Health and Disorders Children's Hospital of Chongqing Medical University Chongqing 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