{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:07:11Z","timestamp":1788793631710,"version":"build-2803163510"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary ciliary dyskinesia (PCD) is a rare inherited disease that affects the movement of the respiratory cilia. The main clinical manifestations are chronic upper and lower respiratory symptoms and recurrent lung infections, particularly bacterial and viral infections. Fungal infections are not usually associated with PCD. Allergic bronchopulmonary aspergillosis (ABPA) is a rare complex immune hypersensitivity reaction to <jats:italic>Aspergillus fumigatus<\/jats:italic> reported in patients with asthma and cystic fibrosis. Only three cases of ABPA associated with adult PCD have been described in the literature. Herein, we reported on two cases of ABPA in two boys aged 10 and 13 years with PCD. Both had severe lung disease and chronic <jats:italic>Pseudomonas aeruginosa<\/jats:italic> infections. One patient was diagnosed according to the typical clinical features of ABPA, while the other was diagnosed during a scheduled visit with no clinical changes but worsening pulmonary function and radiologic anomalies. The diagnosis of ABPA was confirmed in the two patients who then improved after receiving specific treatment. These two cases were the first to describe the occurrence of ABPA in children with PCD. We recommend that physicians involved in the management of children with PCD be aware of this potential complication.<\/jats:p>","DOI":"10.1002\/ppul.25945","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T04:21:13Z","timestamp":1651033273000},"page":"1809-1813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Primary ciliary dyskinesia and fungal infections: Two cases of allergic bronchopulmonary aspergillosis in children"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8711-8631","authenticated-orcid":false,"given":"Laura","family":"Allaer","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Respirology CHU Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7009-2113","authenticated-orcid":false,"given":"St\u00e9phanie","family":"Lejeune","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and Allergy Department, H\u00f4pital Jeanne de Flandre, CHU Lille Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Mordacq","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and Allergy Department, H\u00f4pital Jeanne de Flandre, CHU Lille Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Deschildre","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and Allergy Department, H\u00f4pital Jeanne de Flandre, CHU Lille Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3365-2035","authenticated-orcid":false,"given":"Caroline","family":"Thumerelle","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and Allergy Department, H\u00f4pital Jeanne de Flandre, CHU Lille Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"10","article-title":"Allergic bronchopulmonary aspergillosis in an adult with Kartagener syndrome","volume":"2015","author":"Sehgal IS","year":"2015","journal-title":"BMJ Case Rep"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13357"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/376525"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/atm.ATM_231_16"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fped.2017.00135","article-title":"Primary ciliary dyskinesia: an update on clinical aspects, genetics, diagnosis, and future treatment strategies","volume":"5","author":"Mirra V","year":"2017","journal-title":"Front Pediatr"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.25945","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T11:34:08Z","timestamp":1704972848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.25945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,17]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/ppul.25945"],"URL":"https:\/\/doi.org\/10.1002\/ppul.25945","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,17]]},"assertion":[{"value":"2021-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}