{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:24:06Z","timestamp":1782231846748,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T00:00:00Z","timestamp":1652486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>It is not clear whether asthma, the most frequent chronic disease in childhood, is a risk for severe SARS\u2010CoV\u20102 infection in the pediatric population and how SARS\u2010CoV\u20102 infection affects the lung functions in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We aimed to investigate the course and the consequences of SARS\u2010CoV\u20102 infection among children with asthma and determine the risk factors for the decline in lung function tests (LFTs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, asthmatic children with coronavirus disease 2019 (COVID\u201019) were compared with a random control group of asthmatic patients without COVID\u201019. In addition, the clinical course and the effect on LFTs of COVID\u201019 among children with asthma were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred eighty\u2010nine patients who had COVID\u201019, and 792 who did not were included in the study. Fever, fatigue, and cough were the most frequent symptoms during COVID\u201019. Regarding the severity of COVID\u201019, 163 patients (87.6%) had a mild clinical condition, 13 (7%) had moderate disease, 1 (0.5%) had severe disease, and 2 had (1.1%) critically ill disease. Two patients were diagnosed with multisystem inflammatory syndrome in children (MIS\u2010C), one patient suffered from pneumothorax. LFTs of the patients before and after COVID\u201019 infection were analyzed; no significant differences were found in FEV<jats:sub>1<\/jats:sub>% (91.7% vs. 90.9%, <jats:italic>p\u2009<\/jats:italic>=\u20090.513), FVC% (89.8% vs. 90.8%, <jats:italic>p\u2009<\/jats:italic>=\u20090.502) and FEV<jats:sub>1<\/jats:sub>\/FVC (103.1% vs. 100.6%, <jats:italic>p\u2009<\/jats:italic>=\u20090.056), while FEF25%\u201375% values (107.6% vs. 98.4%, <jats:italic>p\u2009<\/jats:italic>&lt;\u20090.001) were significantly lower after the COVID\u201019 infection. Obesity (odds ratio [OR]: 3.785, 95% confidence interval [CI]: 1.152\u201312.429, <jats:italic>p<\/jats:italic>\u2009=\u20090.028] and having a family history of atopy (OR: 3.359, 95%\u00a0CI: 1.168\u20139.657, <jats:italic>p<\/jats:italic>\u2009=\u20090.025] were found to be the independent risk factors for \u226525% decrease in FEF25\u201375 after COVID\u201019 infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>COVID\u201019 infection leads to dysfunction of the small airways in asthmatic children and obesity is an independent risk factor for a \u226525% decrease in FEF25\u201375. The long\u2010term effects of COVID\u201019 infection especially on small airways\u00a0require close monitoring in children with asthma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25949","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T06:58:47Z","timestamp":1651561127000},"page":"1668-1676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Obesity is a risk factor for decrease in lung function after COVID\u201019 infection in children with asthma"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2329-7543","authenticated-orcid":false,"given":"Elif","family":"Soyak Aytekin","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umit M.","family":"Sahiner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevda","family":"Tuten Dal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"Unsal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozan","family":"Hakverdi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna","family":"Oguz","sequence":"additional","affiliation":[{"name":"Department of Radiology Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Ozsurekci","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Disease Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulent E.","family":"Sekerel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-251X","authenticated-orcid":false,"given":"Ozge","family":"Soyer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-0702"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.1948"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.93.06101455"},{"issue":"4","key":"e_1_2_9_5_1","first-page":"280","article-title":"Extent and burden of allergic diseases in elementary schoolchildren: a national multicenter study","volume":"20","author":"Civelek E","year":"2010","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00409-2020"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24909"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13709"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10051021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01625-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02992-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2019.1674649"},{"key":"e_1_2_9_13_1","unstructured":"Health NIo. 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