{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:34:11Z","timestamp":1788996851163,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Admission to a pediatric intensive care unit (PICU) has been associated with respiratory consequences in children with asthma and carries major implications for management control. Whereas respiratory syncytial virus (RSV) bronchiolitis has been associated with increasing intensity of wheezing, the relationship between RSV\u2010bronchiolitis PICU admission and future asthma is unclear. This retrospective case\u2010control study evaluated whether hospitalization in the PICU due to RSV bronchiolitis is more likely to be associated with future asthma in early life compared with hospitalization in a general pediatric ward.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children hospitalized due to RSV bronchiolitis between 2007 and 2019 in the PICU (study group) were compared to those hospitalized in a general pediatric ward (controls). Asthma prevalence was assessed by a follow\u2010up questionnaire based on The International Study of Asthma and Allergies in Childhood questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010three PICU patients and 66 controls were included. The PICU patients presented with more severe disease during RSV hospitalization. At follow\u2010up, significantly more PICU patients aged 3\u20136 years had physician\u2010diagnosed asthma, respiratory symptoms during the previous 12 months, and underwent respiratory treatment since hospital discharge compared to controls (14 [60.9%] vs. 4 [18.2%] patients; 15 [65.2%] vs. 6 [27.3%]; and 16 [69.6%] vs. 8 [36.4%]; respectively). These differences were no longer observed after 6 years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children admitted to the PICU for RSV bronchiolitis are at higher risk for asthma in subsequent pre\u2010school years and will require close respiratory follow\u2010up than those admitted to general pediatric wards. Admission venue should be queried when asthma is suspected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.25953","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T05:55:06Z","timestamp":1652766906000},"page":"1677-1683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Asthma risk after a pediatric intensive care unit admission for respiratory syncytial virus bronchiolitis"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-2249","authenticated-orcid":false,"given":"Moria","family":"Be'er","sequence":"first","affiliation":[{"name":"Pediatric Pulmonology Unit, Dana\u2010Dwek Children's Hospital Tel\u2010Aviv Sourasky Medical Center (affiliated to the Sackler Faculty of Medicine, Tel Aviv University)  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shai","family":"Bushmitz","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Dana\u2010Dwek Children's Hospital Tel\u2010Aviv Sourasky Medical Center (affiliated to the Sackler Faculty of Medicine, Tel Aviv University)  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4303-9952","authenticated-orcid":false,"given":"Michal","family":"Cahal","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Dana\u2010Dwek Children's Hospital Tel\u2010Aviv Sourasky Medical Center (affiliated to the Sackler Faculty of Medicine, Tel Aviv University)  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efraim","family":"Sadot","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Dana\u2010Dwek Children's Hospital Tel\u2010Aviv Sourasky Medical Center (affiliated to the Sackler Faculty of Medicine, Tel Aviv University)  Tel Aviv Israel"},{"name":"Pediatric Intensive Care Unit, Dana\u2010Dwek Children's Hospital Tel\u2010Aviv Sourasky Medical Center (affiliated to the Sackler Faculty of Medicine, Tel Aviv University)  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivan","family":"Yochpaz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dana\u2010Dwek Children's Hospital Tel\u2010Aviv Sourasky Medical Center (affiliated to the Sackler Faculty of Medicine, Tel Aviv University)  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8226-9318","authenticated-orcid":false,"given":"Omri","family":"Besor","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Dana\u2010Dwek Children's Hospital Tel\u2010Aviv Sourasky Medical Center (affiliated to the Sackler Faculty of Medicine, Tel Aviv University)  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6917-5285","authenticated-orcid":false,"given":"Israel","family":"Amirav","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Dana\u2010Dwek Children's Hospital Tel\u2010Aviv Sourasky Medical Center (affiliated to the Sackler Faculty of Medicine, Tel Aviv University)  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7498-7085","authenticated-orcid":false,"given":"Moran","family":"Lavie","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Dana\u2010Dwek Children's Hospital Tel\u2010Aviv Sourasky Medical Center (affiliated to the Sackler Faculty of Medicine, Tel Aviv University)  Tel Aviv 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