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A broad range of neurocognitive performance has been reported in CCHS, including an array of cognitive deficits. We administered the <jats:italic>NIH Toolbox<\/jats:italic>\u00ae <jats:italic>Cognition Battery<\/jats:italic> (<jats:italic>NTCB<\/jats:italic>), a novel technology comprised of seven tasks presented via an interactive computer tablet application, to a CCHS cohort and studied its convergent and divergent validity relative to traditional clinical neurocognitive measures. The NTCB was administered to 51 CCHS participants, including a subcohort of 24 who also received traditional clinical neurocognitive testing (Wechsler Intelligence Scales). Age\u2010corrected NTCB scores from the overall sample and subcohort were compared to population norms. Associations between NTCB indices and Wechsler Intelligence scores were studied to determine the convergent and divergent validity of the NTCB.\u00a0NTCB test results indicated reduced Fluid Cognition, which measures new learning and speeded information processing (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but intact Crystallized Cognition, which measures past learning, in CCHS relative to population norms. Moderate to strong associations (r\u2009&gt;\u20090.60) were found between age\u2010corrected NTCB Fluid and Crystallized indices and comparable Wechsler indices, supporting the convergent and discriminant validity of the NTCB. Results reveal deficits of Fluid Cognition in individuals with CCHS and indicate that the NTCB is a valid and sensitive measure of cognitive outcomes in this population. Our findings suggest that the NTCB may play a useful role in tracking neurocognition in CCHS.<\/jats:p>","DOI":"10.1002\/ppul.25973","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T08:39:36Z","timestamp":1652690376000},"page":"2040-2047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neurocognitive monitoring in congenital central hypoventilation syndrome with the <i>NIH Toolbox<\/i>\u00ae"],"prefix":"10.1002","volume":"57","author":[{"given":"Remi Z.","family":"Welbel","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Autonomic Medicine Ann &amp; Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey M.","family":"Rand","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Autonomic Medicine Ann &amp; Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Autonomic Medicine Ann &amp; Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allaa","family":"Fadl\u2010Alla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Autonomic Medicine Ann &amp; Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maida Lynn","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pulmonary and Sleep Medicine University of Washington School of Medicine, Seattle Children's Hospital Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6061-220X","authenticated-orcid":false,"given":"Debra E.","family":"Weese\u2010Mayer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Autonomic Medicine Ann &amp; Robert H. 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