{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:40:56Z","timestamp":1781286056820,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Surfactant dosing and effective delivery could affect\u00a0continuous positive airways pressure (CPAP)\u2010failure. Nevertheless, information on exogenous surfactant dosing with current administration methods is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the effect of 100 or 200\u2009mg\/kg of surfactant as first\u2010line treatment of respiratory distress syndrome in preterm infants of less than 32 weeks gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A retrospective single\u2010center cohort study comparing two epochs, before and after switching from 100 to 200\u2009mg\/kg surfactant therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six hundred and fifty\u2010eight\u00a0of the 1615 infants of less than 32 weeks were treated with surfactant: 282 received 100\u2009mg\/kg (S\u2010100) and 376 received 200\u2009mg\/kg (S\u2010200). There were no differences between S\u2010100 and S\u2010200 in perinatal data including prenatal corticosteroids, medication use, age at first surfactant administration and respiratory severity before surfactant.<\/jats:p><jats:p>The S\u2010200 vs. S\u2010100 had fewer retreatments (17.0% vs. 47.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and a shorter duration of oxygen therapy and mechanical ventilation (315 vs. 339\u2009h, <jats:italic>p<\/jats:italic>\u2009=\u20090.018; 37 vs. 118\u2009h, <jats:italic>p<\/jats:italic>\u2009=\u20090.000, respectively). There was no difference in postnatal corticosteroid use (S\u2010200 10.0% vs. S\u2010100 11.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.361). Bronchopulmonary dysplasia (BPD) was significantly lower in S\u2010200 vs. S\u2010100 when comparing either the 4 and 6\u2010year periods before and after the dose switch (29.4% vs. 15.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.003, and 18.7% vs. 27.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.024, respectively)<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The switch from 100 to 200\u2009mg\/kg was associated with a marked reduction in the need for surfactant redosing, respiratory support, and BPD. This information could be important when designing a study in the modern era of less invasive administration as surfactant dosing and its effective delivery may affect the outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25979","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T02:33:05Z","timestamp":1652754785000},"page":"2067-2073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Respiratory distress syndrome in preterm infants of less than 32 weeks: What difference does giving 100 or 200\u2009mg\/kg of exogenous surfactant make?"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7608-9804","authenticated-orcid":false,"given":"Lucia","family":"Lanciotti","sequence":"first","affiliation":[{"name":"Department of Odontostomatologic and Specialized Clinical Sciences Polytechnic University of Marche Ancona (AN) Italy"},{"name":"Division of Neonatology, Mother and Child Department G. 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Salesi University Hospital, Ospedali Riuniti Ancona (AN) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Giorgetti","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Mother and Child Department G. Salesi University Hospital, Ospedali Riuniti Ancona (AN) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Colombo","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Mother and Child Department G. Salesi University Hospital, Ospedali Riuniti Ancona (AN) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L.","family":"Palazzi","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Mother and Child Department G. 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