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Determining whether and how child maltreatment causes or worsens asthma would have major implications for disease prevention and treatment, as well as public health policy. In this article, we examine epidemiologic studies of child maltreatment and asthma and asthma\u2010related outcomes, review the evidence for potential mechanisms underlying the child maltreatment\u2010asthma association, and discuss future directions. To date, a child maltreatment\u2010asthma link has been reported in most studies of children and adults, though the type of maltreatment associated with asthma has differed across studies. Such discrepant findings are likely explained by differences in study design and quality. All studies have been limited by potential under\u2010reporting of child maltreatment and selection bias, and nonthorough assessment of asthma. Despite these limitations, the aggregate evidence from epidemiologic studies suggests a possible causal link between child maltreatment and asthma, though the relative contributions of various types of maltreatment (physical, sexual, emotional, or neglect) are unclear. To date, there is insufficient evidence of an association between child maltreatment and lung function in children or adults. Limited evidence further suggests that child maltreatment could influence the development or severity of asthma through direct effects on stress responses and anxiety\u2010 or depressive\u2010related disorders, immunity, and airway inflammation, as well as indirect effects such as increased obesity risk. Future prospective studies should aim to adequately characterize both child maltreatment and asthma, while also assessing relevant covariates and biomarkers of stress, immune, and therapeutic responses.<\/jats:p>","DOI":"10.1002\/ppul.25982","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T09:30:35Z","timestamp":1652866235000},"page":"1973-1981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Child maltreatment and asthma"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4618-2984","authenticated-orcid":false,"given":"Kristina","family":"Gaietto","sequence":"first","affiliation":[{"name":"Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-5320","authenticated-orcid":false,"given":"Juan C.","family":"Celed\u00f3n","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","first-page":"\u200b","article-title":"Pediatric asthma: a global epidemic","volume":"85","author":"Serebrisky D","year":"2019","journal-title":"Ann Glob Heal"},{"key":"e_1_2_8_3_1","unstructured":"National Data. 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