{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:21:24Z","timestamp":1771262484628,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe characteristics, outcomes, and risk factors for death or tracheostomy with home mechanical ventilation in full\u2010term infants with chronic lung disease (CLD) admitted to regional neonatal intensive care units.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>This was a multicenter, retrospective cohort study of infants born \u226537 weeks of gestation in the Children's Hospitals Neonatal Consortium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 67,367 full\u2010term infants admitted in 2010\u20132016, 4886 (7%) had CLD based on receiving respiratory support at either 28 days of life or discharge. 3286 (67%) were still hospitalized at 28 days receiving respiratory support, with higher mortality risk than those without CLD (10% vs. 2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). A higher proportion received tracheostomy (13% vs. 0.3% vs. 0.4%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and gastrostomy (30% vs. 1.7% vs. 3.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared to infants with CLD discharged home before 28 days and infants without CLD, respectively. The diagnoses and surgical procedures differed significantly between the two CLD subgroups. Small for gestational age, congenital pulmonary, airway, and cardiac anomalies and bloodstream infections were more common among infants with CLD who died or required tracheostomy with home ventilation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Invasive ventilation at 28 days was independently associated with death or tracheostomy and home mechanical ventilation (odds ratio 7.6, 95% confidence interval 5.9\u20139.6, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Full\u2010term infants with CLD are at increased risk for morbidity and mortality. We propose a severity\u2010based classification for CLD in full\u2010term infants. Future work to validate this classification and its association with early childhood outcomes is necessary.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25983","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T04:15:45Z","timestamp":1652760945000},"page":"2082-2091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic lung disease in full\u2010term infants: Characteristics and neonatal intensive care outcomes in infants referred to children's hospitals"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8307-6569","authenticated-orcid":false,"given":"Michel","family":"Mikhael","sequence":"first","affiliation":[{"name":"Neonatal\u2010Perinatal Medicine Division Children's Hospital of Orange County Orange California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Cleary","sequence":"additional","affiliation":[{"name":"Neonatal\u2010Perinatal Medicine Division Children's Hospital of Orange County Orange California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Zaniletti","sequence":"additional","affiliation":[{"name":"Children's Hospital Association Lenexa Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Truog","sequence":"additional","affiliation":[{"name":"Children's Mercy Kansas City University of Missouri Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0258-1246","authenticated-orcid":false,"given":"John","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine Magee\u2010Women's Hospital of UPMC\/Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"DiGeronimo","sequence":"additional","affiliation":[{"name":"Seattle Children's Hospital University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-4487","authenticated-orcid":false,"given":"Alain","family":"Cuna","sequence":"additional","affiliation":[{"name":"Children's Mercy Kansas City University of Missouri Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4568-9070","authenticated-orcid":false,"given":"Matthew J.","family":"Kielt","sequence":"additional","affiliation":[{"name":"Division of Neonatology Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5096-4030","authenticated-orcid":false,"given":"Carl H.","family":"Coghill","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Children's of Alabama University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpa","family":"Vyas\u2010Read","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushmita","family":"Yallapragada","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Engle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Riley Hospital for Children, Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmin C.","family":"Savani","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karna","family":"Murthy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ann and Robert H. 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