{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:53:24Z","timestamp":1747151604559,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The use of emergency department (ED)\u2010initiated outpatient oxygen therapy has been considered to be a possible alternative to hospitalization for otherwise healthy\u2010appearing, well\u2010hydrated infants with uncomplicated disease. However, a formal economic evaluation of this treatment strategy is lacking. The aim of the present study was to compare the cost\u2010effectiveness of ED\u2010initiated outpatient oxygen therapy versus conventional inpatient hospitalization in infants with uncomplicated hypoxic bronchiolitis living in Bogota, the high\u2010altitude capital city of Colombia, a middle\u2010income country (MIC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A decision analysis model was developed to estimate the cost\u2010effectiveness of ED\u2010initiated outpatient oxygen therapy versus hospitalization. The main outcome of the model was avoidance of admission to a high\u2010dependency unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to hospitalization, ED\u2010initiated outpatient oxygen therapy was associated with lower total costs (US$306.7 vs. US$638.7 average cost per patient) and a higher probability of avoidance of admission to a high\u2010dependency unit (0.9528 vs. 0.8960), thus leading to dominance. The results were robust to deterministic and probabilistic sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that in infants attending the ED with an uncomplicated hypoxic bronchiolitis episode in the city of Bogota, a high\u2010altitude city, ED\u2010initiated outpatient oxygen therapy is a dominant strategy compared to conventional inpatient hospitalization, because it involves a higher probability of avoidance of admission to a high\u2010dependency unit, at lower total treatment costs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26018","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T10:03:50Z","timestamp":1653645830000},"page":"2154-2160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Emergency department\u2010initiated home oxygen for viral bronchiolitis: A cost\u2010effectiveness analysis"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2560-6693","authenticated-orcid":false,"given":"Carlos E.","family":"Rodr\u00edguez\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine Universidad Nacional de Colombia  Bogota Colombia"},{"name":"Department of Pediatric Pulmonology, School of Medicine Universidad El Bosque  Bogota Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica P.","family":"Sossa\u2010Brice\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Universidad Nacional de Colombia  Bogota Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8621-6109","authenticated-orcid":false,"given":"Gustavo","family":"Nino","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonary, Sleep Medicine and Integrative Systems Biology, Center for Genetic Research, Children's National Medical Center George Washington University  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30938-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/13.Supplement_6.S454"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/317655"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.1.e45"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.158.6.527"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2092"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0889"},{"issue":"10","key":"e_1_2_9_9_1","first-page":"1","article-title":"Acute bronchiolitis: assessment and management in the emergency department","volume":"16","author":"Joseph MM","year":"2019","journal-title":"Pediatr\u00a0Emerg\u00a0Med\u00a0Pract"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2019.04.004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1872"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1322"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.144709"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.13179"},{"key":"e_1_2_9_15_1","unstructured":"Cost\u2010Effective Analysis. 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