{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T21:35:22Z","timestamp":1774992922106,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Dynamic hyperinflation (DH) is a major contributor to exercise intolerance in patients with obstructive lung diseases. However, it has not been investigated in children with bronchiectasis (BE). We aimed to investigate dynamic ventilatory responses and their influence on functional exercise capacity in children with BE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty children with BE (mean\u00a0forced expiratory volume in 1\u2009s [FEV<jats:sub>1<\/jats:sub>]\u2009=\u200978\u2009\u00b1\u200919%pred) were included. Six\u2010minute walk test (6MWT) was conducted using Spiropalm 6MWT\u00ae for evaluating dynamic ventilatory responses including inspiratory capacity (IC), minute ventilation (VE), breathing reserve (BR) and respiratory rate (RR). A decrease of \u2265100\u2009ml in IC during exertion was defined as DH. Also, spirometry was performed, and peripheral muscle strength were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients (50%) developed DH, and four patients (10%) were ventilatory limited (BR\u2009&lt;\u2009%30) during 6MWT. There was a 176 [100\u2212590]\u2009ml decrease in IC after exertion in patients with DH. DH did not correlate to clinical or functional indicators of the disease, except for an increase in RR (\u2206RR) during exertion. High \u2206RR was associated with presence of DH (<jats:italic>r<\/jats:italic><jats:sub>pb<\/jats:sub>=\u20090.390; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Clinical features, peripheral muscle strength, and Spiropalm 6MWT metrics including 6MWT distance did not differ between patients with and without DH. Univariate analysis revealed FVC% (<jats:italic>R<\/jats:italic>\u2009=\u20090.340), VE<jats:sub>peak<\/jats:sub> (<jats:italic>R<\/jats:italic>\u2009=\u20090.565), quadriceps strength (<jats:italic>R<\/jats:italic>\u2009=\u20090.698) and handgrip strength (<jats:italic>R<\/jats:italic>\u2009=\u20090.711) were the only predictors of 6MWT distance (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although DH is common in children with BE, the severity of DH is rather low and may not seem to affect functional exercise capacity. However, peripheral muscle strength was a major contributor to functional exercise capacity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26028","type":"journal-article","created":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T04:28:51Z","timestamp":1654316931000},"page":"2218-2226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Investigation of dynamic hyperinflation and its relationship with exercise capacity in children with bronchiectasis"],"prefix":"10.1002","volume":"57","author":[{"given":"Beyza Nur","family":"Caglar Tosun","sequence":"first","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation, Graduate Education Institute Izmir Bakircay University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9749-315X","authenticated-orcid":false,"given":"Melih","family":"Zeren","sequence":"additional","affiliation":[{"name":"Department 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