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Here, we first review how regulation of the synthesis, activation, transmembrane transport, target interaction, and degradation of <jats:sc>l<\/jats:sc>\u2010CSNO can affect the ventilatory drive. In particular, we review <jats:sc>l<\/jats:sc>\u2010CSNO formation by hemoglobin R to T conformational change and by nitric oxide (NO) synthases (NOS), and the downstream effects on v\u0307<jats:sub>E<\/jats:sub> through interaction with voltage\u2010gated K<jats:sup>+<\/jats:sup> (Kv) channel proteins and other targets in the peripheral and central nervous systems. We will review how these effects are independent of\u2014and, in fact may be opposite to\u2014those of NO. Next, we will review evidence that specific elements of this pathway may underlie disorders of respiratory control in childhood. Finally, we will review the potential clinical implications of this pathway in the development of respiratory stimulants, with a particular focus on potential pediatric applications.<\/jats:p>","DOI":"10.1002\/ppul.26036","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T09:33:21Z","timestamp":1656927201000},"page":"2291-2297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["S\u2010Nitroso\u2010<scp>l<\/scp>\u2010cysteine and ventilatory drive: A pediatric perspective"],"prefix":"10.1002","volume":"57","author":[{"given":"Dallin","family":"Hubbard","sequence":"first","affiliation":[{"name":"Division of Pediatric Pulmonology Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaylee","family":"Tutrow","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8794-1062","authenticated-orcid":false,"given":"Benjamin","family":"Gaston","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24856"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c090009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2018.1445970"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.4.2478"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01188-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000181714.94827.5d"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.11.027"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/35093117"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1584PP"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1502285112"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021113-170352"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2009.02.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2010.10.012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/34402"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/35093117"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.5.2068"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(94)90022-1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100746200"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi201818c"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.6.3264"},{"key":"e_1_2_9_22_1","unstructured":"MarozkinaN PiedimonteG CottrellL et al. 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