{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:15:35Z","timestamp":1740104135432,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Noninvasive ventilation has become a staple in the care of premature infants. However, failure rates continue to be high in this population. Modifications to noninvasive support, such as nasal intermittent positive pressure ventilation (NIPPV), are used clinically to reduce such failure. Previous in vitro studies have shown improved CO<jats:sub>2<\/jats:sub> clearance when superimposing high\u2010frequency oscillations onto bubble\u00a0continuous positive airway pressure\u00a0(BCPAP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the CO<jats:sub>2<\/jats:sub> clearance of NIPPV to BCPAP with an in\u2010line high\u2010frequency interrupter (HFI) in a premature infant lung model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A premature infant lung model was connected to either a Dr\u00e4ger VN500 for delivery of NIPPV or a BCPAP device with superimposed high\u2010frequency oscillations generated by an in\u2010line HFI. Change in end\u2010tidal CO<jats:sub>2<\/jats:sub>\u00a0(ETCO<jats:sub>2<\/jats:sub>) and mean airway pressure at the simulated trachea were measured and compared for both noninvasive modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Superimposing HF oscillations onto BCPAP with an in\u2010line HFI resulted in improved CO<jats:sub>2<\/jats:sub> clearance relative to BCPAP alone for all tested oscillation frequencies at all CPAP levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). NIPPV also resulted in improved CO<jats:sub>2<\/jats:sub>\u00a0clearance relative to nasal CPAP (NCPAP) alone (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Among the tested settings, BCPAP with an in\u2010line HFI resulted in decreased ETCO<jats:sub>2<\/jats:sub> relative to BCPAP ranging from \u201314% to \u201336%, while NIPPV resulted in decreased ETCO<jats:sub>2<\/jats:sub>\u00a0relative to NCPAP ranging from \u20132% to \u201312%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Superimposing high\u2010frequency oscillations onto BCPAP using a novel in\u2010line HFI was found to be more effective at clearing CO<jats:sub>2<\/jats:sub> than NIPPV in a premature infant lung model.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26039","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T08:49:22Z","timestamp":1655714962000},"page":"2356-2362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of nasal intermittent positive pressure ventilation and bubble CPAP with an in\u2010line high\u2010frequency interrupter in a premature infant lung model"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3687-7325","authenticated-orcid":false,"given":"David M.","family":"Rub","sequence":"first","affiliation":[{"name":"Division of Neonatology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9756-3261","authenticated-orcid":false,"given":"Emidio M.","family":"Sivieri","sequence":"additional","affiliation":[{"name":"Division of Neonatology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"},{"name":"CHOP Newborn Care at Pennsylvania Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soraya","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Division of Neonatology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"CHOP Newborn Care at Pennsylvania Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Sieberlich","sequence":"additional","affiliation":[{"name":"CHOP Newborn Care at Pennsylvania Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric C.","family":"Eichenwald","sequence":"additional","affiliation":[{"name":"Division of Neonatology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"CHOP Newborn Care at Pennsylvania Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5980"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499361"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3985"},{"issue":"2","key":"e_1_2_10_6_1","article-title":"Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation","volume":"2017","author":"Lemyre B","year":"2017","journal-title":"Cochrane Database Syst 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