{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:56:43Z","timestamp":1773385003230,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>With improved survival in neonates with meconium aspiration syndrome (MAS), the focus is currently on mitigating the morbidities. The objective of this study was to predict factors determining prolonged hospital stay in neonates with MAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>It was a retrospective cohort from five centers of south India between 2018 and 2020. Neonates \u226535 weeks of gestation admitted to neonatal intensive care unit\u00a0with the diagnosis of MAS and requiring oxygen beyond 24\u2009h of life were included in the study. The morbidities in the neonates with stay \u22647 days (short stay) were compared with &gt;7 days (prolonged stay). Logistic regression by the backward stepwise method was used for predictive score creation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 347 neonates with MAS discharged home, 103 (29%) had a short stay and 244 (71%) had prolonged stay. The primary support beyond O<jats:sub>2<\/jats:sub> (continuous positive airway pressure\/mechanical ventilation) (42% vs. 83%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), fractional inspired oxygen (FiO<jats:sub>2<\/jats:sub>) at 1\u2009h &gt;30% (45% vs. 87%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), hypoxic ischemic encephalopathy\u00a0(HIE) stage\u00a02 or 3 (1% vs. 27%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), moderate\u2013severe persistent pulmonary artery hypertension\u00a0(PPHN) (3% vs. 31%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were independent factors associated with prolonged stay on logistic regression. A prediction model was devised using weighted scores of these four associated morbidities. The clinical score thus developed had 83% sensitivity, 68% specificity for the prediction of prolonged stay (area under curve:\u00a082%, 95% confidence interval [78\u201387], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>More than two\u2010thirds of neonates with MAS had prolonged stay. The primary support beyond oxygen, FiO<jats:sub>2<\/jats:sub> requirement &gt;30%, Moderate to severe PPHN, HIE stage\u00a02 or 3 were predictive of prolonged stay in neonates with MAS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26044","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T17:08:58Z","timestamp":1656349738000},"page":"2383-2389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prediction score for prolonged hospital stay in meconium aspiration syndrome: A multicentric collaborative cohort of south India"],"prefix":"10.1002","volume":"57","author":[{"given":"Poornachandra","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ovum Woman &amp; Child Speciality Hospital Hoskote, Bangalore Rural Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddu","family":"Charki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shri B. 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Patil Medical College Hospital &amp; Research Centre Vijayapura Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3524-0939","authenticated-orcid":false,"given":"Abhishek S.","family":"Aradhya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ovum Woman &amp; Child Speciality Hospital Hoskote, Bangalore Rural Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6259-3118","authenticated-orcid":false,"given":"Shivashankar","family":"Diggikar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ovum Woman &amp; Child Speciality Hospital, Kalyan Nagar Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archana","family":"Bilagi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics St. Philomena's Hospital Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen","family":"Venkatagiri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chinmaya Mission Hospital Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanmaya","family":"Tyagaraj","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shri B. 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