{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:59:24Z","timestamp":1770746364496,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL122215"],"award-info":[{"award-number":["R01HL122215"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rationale<\/jats:title><jats:p>Animal models suggest pre\u2010eclampsia (Pre\u2010E) affects alveolar development, but data from humans are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Assess the impact of Pre\u2010E on airway function, diffusion capacity, and respiratory morbidity in preterm and term infants born from mothers with Pre\u2010E.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Infants born from mothers with and without Pre\u2010E were recruited for this study; term and preterm infants were included in both cohorts. Respiratory morbidity in the first 12 months of life was assessed through monthly phone surveys. Raised volume rapid thoracoabdominal compression and measurement of diffusion capacity of the lung to carbon monoxide (DLCO) were performed at 6 months corrected age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>There were 146 infants in the Pre\u2010E cohort and 143 in the control cohort. The Pre\u2010E cohort was further divided into nonsevere (<jats:italic>N<\/jats:italic>\u2009=\u200941) and severe (<jats:italic>N<\/jats:italic>\u2009=\u2009105) groups. There was no significant difference in DLCO and DLCO\/alveolar volume among\u00a0the three groups. Forced vital capacity was similar among\u00a0the three groups, but the nonsevere Pre\u2010E group had significantly higher forced expiratory flows than the other two groups. After adjusting for multiple covariates including prematurity, the severe Pre\u2010E group had a lower risk for wheezing in the first year of life compared to the other two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010E is not associated with reduced DLCO, lower forced expiratory flows, or increased wheezing in the first year of life. These results differ from animal models and highlight the complex relationships between Pre\u2010E and lung function and respiratory morbidity in human infants.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26064","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T07:51:03Z","timestamp":1657180263000},"page":"2481-2490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Forced expiratory flows and diffusion capacity in infants born from mothers with pre\u2010eclampsia"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4431-0644","authenticated-orcid":false,"given":"Clement L.","family":"Ren","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine Children's Hospital of Philadephia Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics, Perelman School of Medicine University of Pennsylvania Philadelphia 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