{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T19:53:45Z","timestamp":1770494025205,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Antibiotic allergy is a big problem that may affect the treatment and life quality of patients with cystic fibrosis (CF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate predictive factors for confirmed antibiotic hypersensitivity in children with CF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this case\u2013controlled study, we examined 15 patients with CF who had been confirmed with antibiotic allergy. Additionally, we included a control group of age\u2010 and gender\u2010matched 45 CF patients with no antibiotic allergy. The diagnosis of antibiotic allergy was confirmed in the presence of a compatible history and a positive response in the drug skin test or provocation test. Multiple drug hypersensitivity was classified according to the temporal relationship of antibiotics: (i) distant, (ii) simultaneous, and (iii) sequential. The data were analyzed by conditional logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\u03b2\u2010lactam allergy was confirmed in eight patients (ceftazidime <jats:italic>n<\/jats:italic>\u2009=\u20095, piperacillin\u2010tazobactam <jats:italic>n<\/jats:italic>\u2009=\u20093) and non\u2010\u03b2\u2010lactam allergy was confirmed in two patients (ciprofloxacin <jats:italic>n<\/jats:italic>\u2009=\u20091, azithromycin <jats:italic>n<\/jats:italic>\u2009=\u20091). Additionally, multiple drug hypersensitivity in five patients (distant <jats:italic>n<\/jats:italic>\u2009=\u20094, sequential <jats:italic>n<\/jats:italic>\u2009=\u20091), among whom two patients showed hypersensitivity against ceftazidime\/piperacillin\u2010tazobactam+ ciprofloxacin\/levofloxacin, two patients showed hypersensitivity against ceftazidime+ ciprofloxacin <jats:italic>n<\/jats:italic>\u2009=\u20092, and one patient showed hypersensitivity against piperacillin\u2010tazobactam+ amikacin+ trimethoprim\u2010sulfamethoxazole. All patients (<jats:italic>n<\/jats:italic>\u2009=\u200913) with confirmed \u03b2\u2010lactam allergy were meropenem tolerant. Multivariate analysis indicated that immediate reactions (, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and allergic evaluation in the first six months after the reaction (<jats:italic>p<\/jats:italic>\u2009=\u20090.036) were significant risk factors for the prediction of antibiotic hypersensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Beta\u2010lactam antibiotic allergy is the most commonly confirmed drug allergy in children with CF. However, unlike normal children, ceftazidime and piperacillin\u2010tazobactam account for the majority.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26073","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T08:28:15Z","timestamp":1657787295000},"page":"2622-2628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Antibiotic allergy in children with cystic fibrosis: A retrospective case\u2013control study"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9190-6849","authenticated-orcid":false,"given":"Ay\u015fe","family":"Su\u0308leyman","sequence":"first","affiliation":[{"name":"Division of Pediatric Allergy and Immunology, Department of Pediatrics, Istanbul Faculty of Medicine Istanbul University  Istanbul 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