{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:14:45Z","timestamp":1785233685824,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antibiotics have altered pharmacokinetics (PK) in persons with cystic fibrosis (PwCF) during treatment for an acute pulmonary exacerbation (APE). The Cystic Fibrosis Foundation Pulmonary Guidelines\u2013Treatment of Pulmonary Exacerbations do not provide specific recommendations for treatment of methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) lung infections. However, the American Thoracic Society Guidelines recommend vancomycin as the first\u2010line therapy. Only one study has previously described a single dose of intravenous (IV) vancomycin PK in adult PwCF. Our study aimed to describe intermittent IV vancomycin PK at steady\u2010state in adult PwCF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult PwCF who were admitted to University of Utah Hospital between May 11, 2014 and August 31, 2020, and received intermittent IV vancomycin for the treatment of an APE were included in this study. The primary outcome was to describe the drug volume of distribution (Vd), drug clearance, elimination half\u2010life, and total daily dose of vancomycin. Secondary outcomes were rates of acute kidney injury (AKI), liver injury, and infusion\u2010related reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen patients were included. The mean Vd was 0.54\u2009L\/kg on Day 3 and 0.53L\/kg on Day 7. CL<jats:sub>vanco<\/jats:sub> was 5.11L\/h on Day 3 and 4.69\u2009L\/h on Day 7. Zero patients experienced an AKI, two patients experienced liver injury, and no patients experienced infusion\u2010related reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate that in PwCF intermittent IV vancomycin steady\u2010state PK are similar to previously reported single\u2010dose IV vancomycin. Additionally, CL<jats:sub>vanco<\/jats:sub> minimally changes from Day 3 to Day 7, although this study was not powered to detect a difference.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26077","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T04:08:26Z","timestamp":1657858106000},"page":"2646-2651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacokinetics of intermittent dosed intravenous vancomycin in adult persons with cystic fibrosis"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5861-4441","authenticated-orcid":false,"given":"Bryn","family":"Lindley","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services University of Utah Health  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubin","family":"Bhakta","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services University of Utah Health  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services University of Utah Health  Salt Lake City Utah USA"},{"name":"Department of Pharmacotherapy University of Utah College of Pharmacy  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy University of Utah College of Pharmacy  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Leclair","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services University of Utah Health  Salt Lake City Utah USA"},{"name":"Department of Internal Medicine University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0977-7257","authenticated-orcid":false,"given":"David C.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services University of Utah Health  Salt Lake City Utah USA"},{"name":"Department of Pharmacotherapy University of Utah College of Pharmacy  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2021.1836157"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201402-050AS"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200812-1845PP"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014567526"},{"key":"e_1_2_10_6_1","unstructured":"KoffJL. 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