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The Leicestershire respiratory cohort (LRC) has developed a noninvasive asthma prediction tool (APT) for children with promising results. We aimed to perform its external validation in the French general population \u00c9tude Longitudinale Fran\u00e7aise depuis l'Enfance\u00a0(ELFE) cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Predictive scores were determined at Age 1 and the primary outcome of asthma was defined as parental reporting of \u201casthma ever or \u201cwheezing in the past 12 months\u201d at Age 5. Logistic regression was used to calculate the odds ratio (OR) and performance measures, and discriminative performance was reported using the\u00a0receiver operating curve and area under curve\u00a0(AUC). Calibration was assessed using Hosmer\u2013Lemeshow goodness\u2010of\u2010fit test and visualized with a calibration plot. Overall performance was determined using Brier scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 10,689 children analyzed: 84.9% were at low, 13.1% medium, and 2% at high risk of developing asthma at Age 5. Children in the medium\u2010risk category were three times more likely to develop asthma (OR\u2009=\u20093.3, 95% confidence interval [CI]\u2009=\u20092.97\u20133.78) whereas 13 times more likely in the high\u2010risk category (OR\u2009=\u200913.8, 95% CI\u2009=\u200910.2\u201318.8). The tool's AUC was comparable: LRC 0.74 versus\u00a0ELFE 0.68; as were the Brier scores LRC 0.16 versus\u00a0ELFE 0.14. The tool's performance was robust to changes in inclusion criteria and outcome definitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Results of the present study and previous validation studies performed in high\u2010risk populations provide a comprehensive measure of the effectiveness of the APT, providing encouragement for its application by general practitioners.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26085","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T02:09:50Z","timestamp":1659665390000},"page":"2696-2706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The external validation of the asthma prediction tool in the French ELFE cohort"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5560-6996","authenticated-orcid":false,"given":"Sadia","family":"Khan","sequence":"first","affiliation":[{"name":"Bordeaux Population Health Research Center, EPICENE Team,\u00a0INSERM, UMR 1219 Bordeaux University Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El Hassane","family":"Ouaalaya","sequence":"additional","affiliation":[{"name":"Bordeaux Population Health Research Center, EPICENE Team,\u00a0INSERM, UMR 1219 Bordeaux University Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonviea D.","family":"Chamberlain","sequence":"additional","affiliation":[{"name":"Bordeaux Population Health Research Center, Inserm\u00a0UMR 1219 University of Bordeaux Bordeaux France"},{"name":"CIC1401\u2010EC, Inserm Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010No\u00eblle","family":"Dufourg","sequence":"additional","affiliation":[{"name":"INED, Inserm, Joint Unit ELFE Aubervilliers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Aline","family":"Charles","sequence":"additional","affiliation":[{"name":"INED, Inserm, Joint Unit ELFE Aubervilliers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal R.","family":"Semjen","sequence":"additional","affiliation":[{"name":"Bordeaux Population Health Research Center, EPICENE Team,\u00a0INSERM, UMR 1219 Bordeaux University Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"WHO.The global asthma report 2018;2018. 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