{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:45:40Z","timestamp":1782139540224,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Air pollution is strongly associated with asthma, but has not been determined to induce new\u2010onset asthma development in children with atopic dermatitis (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Working Hypothesis<\/jats:title><jats:p>To assess whether prenatal\/postnatal exposure to air pollutants triggers new\u2010onset asthma development in children with AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient\u2010subject Selection<\/jats:title><jats:p>Data of patients &lt;age 18 years diagnosed with eczema or AD between 2009 and 2019 were extracted from the multicenter Kaohsiung Medical University Hospital Research Database. Patients diagnosed with new\u2010onset asthma were in the asthma group and patients without asthma history were in the non\u2010asthma group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>The monthly average concentration of air pollutants for 1, 3, and 5 years before the index date, and 3, 6, and 9 months prenatally were analyzed and further stratified by age, immunoglobulin (Ig) E, and the percentage of eosinophil and eosinophil cationic protein (ECP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postnatal exposure to airborne particulate matter (PM<jats:sub>2.5<\/jats:sub>, PM<jats:sub>10<\/jats:sub>), sulfur dioxide (SO<jats:sub>2<\/jats:sub>), ozone (O<jats:sub>3<\/jats:sub>), carbon monoxide (CO), nitric oxide (NO), nitric dioxide (NO<jats:sub>2<\/jats:sub>), and NO<jats:sub>x<\/jats:sub>, and prenatal exposure to PM<jats:sub>2.5<\/jats:sub>, PM<jats:sub>10<\/jats:sub>, SO<jats:sub>2<\/jats:sub>, NO, and NO<jats:sub>x<\/jats:sub> were significantly higher in the asthma group than in the non\u2010asthma group. Patients having IgE above 100 IU\/ml and ECP less than 24\u2009ng\/ml were significantly influenced by postnatal exposure to PM<jats:sub>2.5<\/jats:sub> and PM<jats:sub>10<\/jats:sub>, especially CO, to develop asthma, and those having an eosinophil count &gt;3% were significantly influenced by prenatal exposure to PM<jats:sub>2.5<\/jats:sub>, especially SO<jats:sub>2<\/jats:sub>, NO, and NO<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prenatal and postnatal exposure to air pollution have an association with asthma development in AD patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26089","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T05:59:22Z","timestamp":1659679162000},"page":"2724-2734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The prenatal and postnatal effects of air pollution on asthma in children with atopic dermatitis"],"prefix":"10.1002","volume":"57","author":[{"given":"I\u2010Lun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, College of Medicine Chang Gung University Kaohsiung Taiwan"},{"name":"School of Traditional Chinese Medicine, College of Medicine Chang Gung University Linkou Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Wei","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Min","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Community Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical 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