{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:14:50Z","timestamp":1740104090212,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vascular rings are congenital anomalies of the aortic arch that compress the trachea and esophagus and may require corrective surgery. Data about the long\u2010term effects of vascular rings are scarce. We aimed to evaluate the long\u2010term cardiorespiratory, exercise capacity, and quality of life of vascular ring patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single center prospective study evaluating spirometry, echocardiography, six\u2010minute walk test (6MWT), cardiopulmonary exercise testing (CPET), and quality of life questionnaire (SF36) in patients with a diagnosis of vascular ring, with or without corrective surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven patients participated (11.9\u2009\u00b1\u20096 years, 52% males). The most common diagnosis was double aortic arch (16 patients, 59%). Nineteen patients had corrective surgery (O) and 8\u00a0did not (NO). Pulmonary function tests were within normal range in both groups (FEV<jats:sub>1<\/jats:sub>% predicted O\u2009=\u200987.6\u2009\u00b1\u200916.5, NO\u2009=\u200983\u2009\u00b1\u200910.8%). However, 11\/27 had abnormal FEV<jats:sub>1<\/jats:sub>, 5\u00a0had abnormal FVC, and 13 (48%) had flattening of the expiratory curve. 6MWD and oxygen uptake were similarly mildly reduced in both groups; (6MWD O\u2009=\u200980.1\u2009\u00b1\u200910.7% predicted, NO\u2009=\u200974.1\u2009\u00b1\u200910.9%\u00a0and oxygen uptake O\u2009=\u200978.5\u2009\u00b1\u200923.2% predicted, NO\u2009=\u200973.4\u2009\u00b1\u200914.3%). Peak O<jats:sub>2<\/jats:sub> pulse (V\u0307O<jats:sub>2<\/jats:sub>\/HR% predicted) was mildly reduced in the NO group (O\u2009=\u200988.4\u2009\u00b1\u200917.3%, NO\u2009=\u200975.8\u2009\u00b1\u200916.2%). Echocardiogram and SF36 scores were normal in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term evaluation of patients born with vascular rings revealed mild pulmonary impairment, reduction in 6MWD, and oxygen uptake. The NO group had also mild reduced peak O<jats:sub>2<\/jats:sub> pulse. Larger, long\u2010term studies assessing functional parameters in operated and non\u2010operated patients are needed to assess disease\/surgery limitation in patients with vascular rings.\u00a0Clinical trial registration number: NCT04781738.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26112","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T04:08:02Z","timestamp":1660622882000},"page":"2946-2953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functional capacity and quality of life in patients with vascular ring"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7279-9294","authenticated-orcid":false,"given":"Vered","family":"Nir","sequence":"first","affiliation":[{"name":"Pediatric Pulmonary Institute, Ruth Children's Hospital, Rambam Health Care Campus Haifa Israel"},{"name":"Technion\u2013Israel Institute of Technology, Bruce Rappaport 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Haifa Israel"},{"name":"Technion\u2013Israel Institute of Technology, Bruce Rappaport Faculty of Medicine Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvi","family":"Adler","sequence":"additional","affiliation":[{"name":"Technion\u2013Israel Institute of Technology, Bruce Rappaport Faculty of Medicine Haifa Israel"},{"name":"Department of Cardiac Surgery Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moneera","family":"Hanna","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Institute, Ruth Children's Hospital, Rambam Health Care Campus Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazeed","family":"Toukan","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Institute, Ruth Children's Hospital, Rambam Health Care Campus Haifa Israel"},{"name":"Technion\u2013Israel Institute of Technology, Bruce Rappaport Faculty of Medicine Haifa 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