{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:56:53Z","timestamp":1791496613557,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The optimal lung volume strategy during high\u2010frequency oscillatory ventilation (HFOV) is reached by performing recruitment maneuvers, usually guided by the response in oxygenation. In animal models, secondary spontaneous change in oscillation pressure amplitude (\u0394Phf) associated with a progressive increase in mean airway pressure during HFOV combined with volume guarantee (HFOV\u2010VG) identifies optimal lung recruitment. The aim of this study was to describe recruitment maneuvers in HFOV\u2010VG and analyze whether changes in \u0394Phf might be an early predictor for lung recruitment in newborn infants with severe respiratory failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>The prospective observational study was done in a tertiary\u2010level neonatology department. Changes in \u0394Phf were analyzed during standardized lung recruitment after initiating early rescue HFOV\u2010VG in preterm infants with severe respiratory failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven\u00a0patients were included, with a median gestational age of 24 weeks (interquartile range\u00a0[IQR]: 23\u201325). Recruitment maneuvers were performed, median baseline mean airway pressure (mPaw) was 11\u2009cm H<jats:sub>2<\/jats:sub>O (IQR: 10\u201313), median critical lung opening mPaw during recruitment was 14\u2009cm H<jats:sub>2<\/jats:sub>O (IRQ: 12\u201316), and median optimal mPaw was 12\u2009cm H<jats:sub>2<\/jats:sub>O (IQR: 10\u201314, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Recruitment maneuvers were associated with an improvement in oxygenation (FiO<jats:sub>2<\/jats:sub>: 65.0 vs. 45.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01, SpO2\/FiO<jats:sub>2<\/jats:sub> ratio: 117 vs. 217, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). \u0394Phf decreased significantly after lung recruitment (mean amplitude: 23.0 vs. 16.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In preterm infants with severe respiratory failure, the lung recruitment process can be effectively guided by \u0394Phf on HFOV\u2010VG.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26124","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T06:10:12Z","timestamp":1661235012000},"page":"3000-3008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lung recruitment in neonatal high\u2010frequency 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