{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T15:01:35Z","timestamp":1774537295017,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on the prevalence and type of lung function impairment in preschool and school\u2010aged children previously diagnosed with persistent tachypnea of infancy (PTI) are scarce. Therefore, this study aims to assess pulmonary function in this age group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children diagnosed with PTI over 3 years old were admitted for follow\u2010up visits and healthy controls were enrolled. The study group included children who were able to complete pulmonary function tests (PFTs). Medical history, physical examination, and pulmonary function (spirometry, body plethysmography, impulse oscillometry, nitrogen multiple breath washout test, diffusing capacity for carbon monoxide [DL<jats:sub>CO<\/jats:sub>]) were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven children (26 boys, 11 girls; median age: 5.6 years) diagnosed with PTI and 37 healthy controls were recruited. Forced expiratory volume in 1\u2009s\u00a0and forced vital capacity were significantly lower (\u22121.12 vs. 0.48, <jats:italic>p<\/jats:italic>\u2009=\u20090.002 and \u22120.83 vs. 0.31, <jats:italic>p<\/jats:italic>\u2009=\u20090.009, respectively); respiratory resistance at 5\u2009Hz (0.06 vs. \u22120.62, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), resonant frequency (1.86 vs. 1.36, <jats:italic>p<\/jats:italic>\u2009=\u20090.04), residual volume\u00a0(RV) (2.34 vs. \u22121.2, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), RV%TLC (total lung capacity) (2.63 vs. \u22120.72, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and specific airway resistance (5.4 vs. 2.59, <jats:italic>p<\/jats:italic>\u2009=\u20090.04) were significantly higher in PTI patients as compared with controls (data were presented as median <jats:italic>z<\/jats:italic>\u2010score). Air trapping was found in 60.0%, and abnormally high lung clearance index and DL<jats:sub>CO<\/jats:sub>\u00a0were found in 73.3% and 90.9% of PTI patients, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated that lung function is affected in most children with PTI. PFTs showed that peripheral airways are the major zone of functional impairment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26162","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T06:49:25Z","timestamp":1664520565000},"page":"81-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pulmonary function in children with persistent tachypnea of infancy"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7455-4362","authenticated-orcid":false,"given":"Honorata","family":"Marczak","sequence":"first","affiliation":[{"name":"Department of Pediatric Pneumology and Allergy Medical University of Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Peradzy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Medical University of Warsaw  Warsaw 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