{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T10:16:13Z","timestamp":1778408173566,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The clinical course of new COVID\u201019 variants in adolescents is still unknown. The aim of this study is to evaluate the clinical characteristics of COVID\u201019 in adolescents and compare the differences between the original version and the delta variant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The medical records of patients aged 10\u221218 years treated for COVID\u201019 between April 1, 2020\u00a0and March 31, 2022 were retrospectively reviewed. Patients were divided into four groups (asymptomatic, mild, moderate, and severe) for COVID\u201019 severity and into two groups according to the diagnosis date (first\u2212second year). The primary endpoint of the study was hospital admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of patients was 171.81\u2009\u00b1\u200929.5 months, and most of them were males (<jats:italic>n<\/jats:italic>: 435, 53.3%). While the patient number was 296 (43.52%) in the first year of pandemic, it raised to 520 (54.11%) in the second year (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The severity of COVID\u201019 was mild in 667 (81.7%) patients. In the comparison of patients according to the diagnosis date (first\u2212second years); the parameters of anosmia, ageusia, weakness, muscle pain, vomiting, hospital admission, and length of stay in hospital were statistically different (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In the comparison of hospitalized patients between years, the necessity of oxygen support (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), endotracheal intubation rates (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), length of stay in the hospital (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and the severity of COVID\u201019 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) was significantly higher in the second year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The clinical course for adolescents diagnosed with COVID\u201019 has linearly changed with the delta variant. Our results confirmed that the delta variant is more transmissible, requires more oxygen support, increases endotracheal intubation, and prolongs the length of stay in the hospital.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26166","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T06:38:37Z","timestamp":1664519917000},"page":"115-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Delta variant effect on the clinical course of adolescent COVID\u201019 patients"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1378-9250","authenticated-orcid":false,"given":"Hanife Tu\u011f\u00e7e","family":"\u00c7a\u011flar","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology, Meram School of Medicine Necmettin Erbakan University Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-902X","authenticated-orcid":false,"given":"Sevgi","family":"Pekcan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Meram School of Medicine Necmettin Erbakan University Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2689-7904","authenticated-orcid":false,"given":"Asl\u0131 \u0130mran","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Meram School of Medicine Necmettin Erbakan University Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4380-7643","authenticated-orcid":false,"given":"G\u00f6k\u00e7en","family":"\u00dcnal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Meram School of Medicine Necmettin Erbakan University Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3465-6994","authenticated-orcid":false,"given":"\u00d6zge","family":"Metin Akcan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Meram School of Medicine Necmettin Erbakan University Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-2519","authenticated-orcid":false,"given":"Mahmut Z.","family":"\u00dcnsa\u00e7ar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Meram School of Medicine Necmettin Erbakan University Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Meram School of Medicine Necmettin Erbakan University Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Ak\u0131n","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency Medicine, Meram School of Medicine Necmettin Erbakan University Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization (WHO). 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Variants: distribution of case data 11 June 2021. 2022.\u00a0Accessed May 10 2022.\u00a0https:\/\/www.gov.uk\/government\/publications\/covid-19-variants-genomically-confirmed-casenumbers\/variants-distribution-of-case-data-11-june-2021"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n1654"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/clinpract11040093"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27526"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.26166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.26166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.26166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T22:20:24Z","timestamp":1692483624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.26166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,6]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/ppul.26166"],"URL":"https:\/\/doi.org\/10.1002\/ppul.26166","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,6]]},"assertion":[{"value":"2022-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}