{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:30:22Z","timestamp":1770748222875,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["20FC1017"],"award-info":[{"award-number":["20FC1017"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mortality prediction of congenital diaphragmatic hernia (CDH)\u00a0is essential for developing treatment strategies, including fetal therapy. Several researchers have reported prognostic factors for this rare but life\u2010threatening condition; however, the optimal combination of prognostic factors remains to be elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to develop the most discriminative prenatal and postnatal models to predict the mortality of infants with an isolated left\u2010sided CDH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multi\u2010institutional retrospective cohort study included infants with CDH born at 15 tertiary hospitals of the Japanese CDH Study Group between 2011 and 2016. We developed multivariable logistic models with every possible combination of predictors and identified models with the highest cross\u2010validated area under the receiver operating characteristic curve (AUC) for prenatal and postnatal predictions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 302 eligible infants, 44 died before discharge. The prenatal mortality prediction model was based on the observed\/expected lung area to head circumference ratio (O\/E LHR), liver herniation, and stomach herniation (AUC, 0.830). The postnatal mortality prediction model was based on O\/E LHR, liver herniation, and the lowest oxygenation index (AUC, 0.944).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our models can facilitate the prenatal and postnatal mortality prediction of infants with isolated left\u2010sided CDH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26172","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:12:56Z","timestamp":1664496776000},"page":"152-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Development of mortality prediction models for infants with isolated,\u00a0left\u2010sided congenital diaphragmatic hernia before and after birth"],"prefix":"10.1002","volume":"58","author":[{"given":"Kota","family":"Yoneda","sequence":"first","affiliation":[{"name":"Division of Neonatology, Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine, 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Center Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Inamura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kindai University, Faculty of Medicine Osaka\u2010Sayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadaharu","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Juntendo University Urayasu Hospital Urayasu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Yamoto","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Shizuoka Children's Hospital Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouji","family":"Masumoto","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Faculty of Medicine University of Tsukuba Tsukuba 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