{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:53:31Z","timestamp":1747151611007,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["072405\/Z\/03\/Z"],"award-info":[{"award-number":["072405\/Z\/03\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Financial code 001"],"award-info":[{"award-number":["Financial code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["477036\/2012\u20100"],"award-info":[{"award-number":["477036\/2012\u20100"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Sufficient vitamin D (25\u2010hydroxyvitamin D [25(OH)D]) serum levels are associated with decreased asthma symptoms. Our aim was to investigate associations between vitamin D and atopy, asthma, asthma severity, and asthma phenotypes in Brazilian teenagers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study involved 942 individuals (11\u201319\u2009years old) engaged in an asthma cohort. The ISAAC questionnaire was employed to diagnosis asthma and asthma severity. Serum allergen\u2010specific immunoglobulin E (sIgE) was measured by ImmunoCap and serum 25(OH)D was measured by ELISA. We calculated the correlation between sIgE and 25(OH)D. We used multivariate logistic regression analysis to assess associations of interest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that 25(OH)D deficiency was positively associated with atopy (OR 1.45, confidence interval [CI] 1.05\u20132.00) and high levels of this vitamin negatively correlated with sIgE to <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic> (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.11, <jats:italic>p<\/jats:italic>\u2009=\u20090.019). The average 25(OH)D serum level was 27.0\u2009\u00b1\u20099.5\u2009ng\/ml; 366 individuals (38.8%) had a sufficient level. There was no association between 25(OH)D and asthma, asthma severity or asthma phenotypes in the population. However, sex was a possible effect modifier of the association between vitamin D and asthma: insufficiency in asthmatic women (86%) was higher than in asthmatic men (42%), and there was an association between insufficient vitamin D levels and greater asthma risk only in women (OR\u2009=\u20093.06, 95% CI 1.16\u20138.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have shown that vitamin D deficiency was associated with greater risk of atopy in both sexes and vitamin D insufficiency was associated with asthma only in women. There was no association between vitamin D levels and asthma phenotypes or asthma severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26200","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T06:53:55Z","timestamp":1666248835000},"page":"297-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum 25\u2010hydroxyvitamin D deficiency is associated with atopy, and sex may be an effect modifier of its association with asthma in teenagers from northeast Brazil"],"prefix":"10.1002","volume":"58","author":[{"given":"Alana","family":"Alcantara Galv\u00e3o","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias da Sa\u00fade Universidade Federal da Bahia (UFBA)  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Em\u00edlia M. M.","family":"de Andrade Belitardo","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias da Sa\u00fade Universidade Federal da Bahia (UFBA)  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via","family":"de Ara\u00fajo Sena","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias da Sa\u00fade Universidade Federal da Bahia (UFBA)  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana M.","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias da Sa\u00fade Universidade Federal da Bahia (UFBA)  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo N.","family":"de Oliveira Costa","sequence":"additional","affiliation":[{"name":"Instituto de Sa\u00fade Coletiva Universidade Federal da Bahia (UFBA)  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline A.","family":"Feitosa","sequence":"additional","affiliation":[{"name":"Instituto de Sa\u00fade Coletiva Universidade Federal da Bahia (UFBA)  Salvador Brazil"},{"name":"Escola Baiana de Medicina e Sa\u00fade P\u00fablica  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemeire L.","family":"Fiaccone","sequence":"additional","affiliation":[{"name":"Instituto de Matem\u00e1tica e Estat\u00edstica Universidade Federal da Bahia  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro A.","family":"Cruz","sequence":"additional","affiliation":[{"name":"ProAR, Faculdade de Medicina Universidade Federal da Bahia, (UFBA)  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio L.","family":"Barreto","sequence":"additional","affiliation":[{"name":"Instituto de Sa\u00fade Coletiva Universidade Federal da Bahia (UFBA)  Salvador Brazil"},{"name":"Centro de Integra\u00e7\u00e3o de Dados e 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