{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T22:51:24Z","timestamp":1792363884895,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Congenital lung malformations (CLMs) are being detected more frequently during pregnancy. There is controversy regarding the optimal treatment for an asymptomatic child with prenatally diagnosed CLMs. Due to the paucity of information from clinical trials, we developed decision analytic models to compare two treatment strategies for such patients\u2014elective surgical resection versus expectant management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We built decision analytic models stratified by lesion size. We used data from English language literature identified through PubMed searches along with estimates from expert opinions of surgical colleagues. We analyzed results for two hypothetical asymptomatic 6\u2010month\u2010old children with CLMs; one has a large lesion occupying more than 50% of the involved lobe, while the other has a small lesion occupying less than 50% of the involved lobe. We used quality\u2010adjusted life years (QALYs) to measure effectiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For an asymptomatic child with a small or large lesion, expectant management resulted in a small gain of 0.09 or 0.15 QALYs, respectively. Sensitivity analyses showed that surgical resection would be preferred if the probability of remaining asymptomatic was low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In contrast to current practice, expectant management may be a better alternative for asymptomatic children born with CLMs. More longitudinal studies are required to improve the accuracy of the model.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26206","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T16:55:38Z","timestamp":1666025738000},"page":"449-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Should asymptomatic patients with congenital lung malformations undergo surgery? A decision analysis"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0108-5638","authenticated-orcid":false,"given":"Weili","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Environmental and Public Health Sciences University of Cincinnati College of Medicine Cincinnati Ohio USA"},{"name":"Department of Pediatric Surgery Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Eckman","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Internal Medicine University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2004.10.022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-981656"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2022.03.021"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3928\/19382359-20190326-02"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21150"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2018.02.065"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513810902984095"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.807236"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00239"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.10.015"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-008-2139-3"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.10.032"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2012.01.002"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304048"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2003.11.021"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.01.014"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-014-3654-z"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588412X13373405387735"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.093716"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X8300300110"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.11.014"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41370-018-0043-z"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-15490"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197707)40:1<383::AID-CNCR2820400154>3.0.CO;2-2"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2017.09.001"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00035"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.34973"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13013-016-0083-x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2013.789057"},{"key":"e_1_2_10_31_1","first-page":"425","article-title":"Congenital cystic malformation of the lung; differential diagnosis and pathologic characteristics in twenty\u2010one cases","volume":"36","author":"Adams WE","year":"1946","journal-title":"J Iowa State Med Soc"},{"issue":"3","key":"e_1_2_10_32_1","first-page":"171","article-title":"Should asymptomatic congenital cystic adenomatous malformations be removed? 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