{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:48:30Z","timestamp":1790351310398,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Assessment of and intervention for sleep\u2010disordered breathing and malnutrition are related to the prevention of recurrent respiratory tract infections (RRTIs) and acute respiratory failure (ARF) in children with spinal muscular atrophy (SMA). However, specific standards for sleep\u2010disordered breathing and malnutrition in the prevention of RRTIs and ARF have not been clarified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The study aimed to identify the risk factors and predictive indices for RRTIs and\/or ARF in children with SMA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, the differences in clinical characteristics between patients with and without RRTIs and ARF were compared, and binary logistic regression analysis was carried out. The optimal cutoff points for positive predictors were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SMA type 1 (odds ratio (OR)\u2009=\u20095.21, 95% confidence interval (CI) 1.50\u201318.17, <jats:italic>p<\/jats:italic>\u2009=\u20090.010) and the apnea\u2010hypopnea index (AHI) (OR\u2009=\u20091.12, 95% CI 1.01\u20131.24, <jats:italic>p<\/jats:italic>\u2009=\u20090.026) were risk factors, while the body mass index z score (BMIz) (OR\u2009=\u20090.65, 95% CI 0.46\u20130.91, <jats:italic>p<\/jats:italic>\u2009=\u20090.013) and mean pulse oxygen saturation (MSpO<jats:sub>2<\/jats:sub>) (OR\u2009=\u20090.72, 95% CI 0.52\u20131.00, <jats:italic>p<\/jats:italic>\u2009=\u20090.049) were protective factors. A standard consisting of (i) MSpO<jats:sub>2<\/jats:sub>\u2009&lt;\u200996% and (ii) AHI\u2009&gt;\u200910 events\/h and\/or BMIz\u2009&lt;\u2009\u20101 predicted the occurrence of RRTIs and\/or ARF in the next year with a sensitivity of 0.513 and a specificity of 0.957.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SMA type 1, BMIz, AHI and MSpO<jats:sub>2<\/jats:sub> should be used to estimate the risk of RRTI and\/or ARF in children with SMA. MSpO<jats:sub>2<\/jats:sub>\u2009&lt;\u200996% combined with AHI\u2009&gt;\u200910 events\/h or BMIz\u2009&lt;\u2009\u20101 should be used as the intervention standard.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26218","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T13:03:20Z","timestamp":1668171800000},"page":"507-515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Risk factors for recurrent respiratory tract infections and acute respiratory failure in children with spinal muscular atrophy"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9372-650X","authenticated-orcid":false,"given":"Wenhui","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Pulmonology, Affiliated Children's Hospital Capital Institute of Pediatrics Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghui","family":"Meng","sequence":"additional","affiliation":[{"name":"Center for Evidence\u2010Based Medicine Capital Institute of Pediatrics Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-1202","authenticated-orcid":false,"given":"Ling","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Affiliated Children's Hospital Capital Institute of Pediatrics Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2017.11.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2017.11.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2019.12.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0b013e318190310f"},{"issue":"3","key":"e_1_2_10_6_1","first-page":"161","article-title":"Clinical diagnosis and treatment path of recurrent respiratory tract infection in children (2022 edition)","volume":"37","author":"Allergy group of Chinese association of pediatricians, Respiration group of Chinese medical association of pediatrics, Rheumatology and immunology group of Chinese association of pediatricians","year":"2022","journal-title":"Chin J Pract Pediatr"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir531"},{"key":"e_1_2_10_8_1","volume-title":"The AASM Manual for Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, Version 2.3","author":"Berry RB","year":"2016"},{"key":"e_1_2_10_9_1","volume-title":"WHO child growth standards: length\/height\u2010for\u2010age, weight\u2010for\u2010age, weight\u2010for\u2010length, weight\u2010for\u2010height and body mass index\u2010for\u2010age: methods and development","author":"World Health Organization","year":"2006"},{"issue":"246","key":"e_1_2_10_10_1","first-page":"2002","article-title":"CDC growth charts for the United States: methods and development. 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