{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:15:28Z","timestamp":1765808128050},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To verify the added value of respiratory function monitor (RFM) to assess ventilation and the heart rate (HR) changes during stabilization of preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Preterm infants &lt;32 weeks' gestation, bradycardic at birth and in need for positive pressure ventilation (PPV) were included. The first 15\u2009min of stabilization was monitored with RFM. Three\u00a0time points were identified according to HR\u00a0values (T0 the start of mask PPV; T1 the HR rise &gt;100\u2009bpm; T2 the delivery of the last PPV). For each inflation, PIP, PEEP, MAP, expired tidal volume\/kg (Vte\/kg), and mean dynamic compliance (Cdyn) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PIP and MAP values were significantly higher at T1 (27.09\u2009\u00b1\u20095.37\u00a0and 17.47\u2009\u00b1\u20093.85\u2009cmH<jats:sub>2<\/jats:sub>O) and at T2 (24.7\u2009\u00b1\u20093.86\u00a0and 15.2\u2009\u00b1\u20093.78\u2009cmH<jats:sub>2<\/jats:sub>O) compared to T0 (24.05\u2009\u00b1\u20092.27 and 15.85\u2009\u00b1\u20092.77\u2009cmH<jats:sub>2<\/jats:sub>O). PEEP at T1 was significantly higher (6.27\u2009\u00b1\u20092.17\u2009cmH<jats:sub>2<\/jats:sub>O) compared to T2 (5.61\u2009\u00b1\u20091.50\u2009cmH<jats:sub>2<\/jats:sub>O). Vte\/kg showed significantly lower T0 values (3.57\u2009\u00b1\u20092.14\u2009ml\/kg) compared to T1 (6.18\u2009\u00b1\u20092.51\u2009ml\/kg) and T2 (6.89\u2009\u00b1\u20092.40\u2009ml\/kg). There was a significant effect of time on Cdyn.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A clear correspondence between HR rise and adequate Vte\/kg during stabilization of very preterm infants was highlighted. RFM might be useful to tailor ventilation, following real\u2010time changes of lung compliance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26229","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T05:04:35Z","timestamp":1667451875000},"page":"550-555","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Tidal volume optimization and heart rate response during stabilization of very preterm infants"],"prefix":"10.1002","volume":"58","author":[{"given":"Francesco","family":"Cavigioli","sequence":"first","affiliation":[{"name":"NICU \u201cV. Buzzi\u201d Children's Hospital ASST\u2010FBF\u2010Sacco Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilia","family":"Bresesti","sequence":"additional","affiliation":[{"name":"NICU \u201cV. Buzzi\u201d Children's Hospital ASST\u2010FBF\u2010Sacco Milan Italy"},{"name":"Department of Medicine and Surgery University of Insubria Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Di Peri","sequence":"additional","affiliation":[{"name":"NICU \u201cV. Buzzi\u201d Children's Hospital ASST\u2010FBF\u2010Sacco Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Cerritelli","sequence":"additional","affiliation":[{"name":"Foundation COME Collaboration Pescara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Gazzolo","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit \u201cG. D'Annunzio\u201d University Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio W. D.","family":"Gavilanes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School for Oncology and Developmental Biology (GROW) Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School for Oncology and Developmental Biology (GROW) Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjan","family":"te Pas","sequence":"additional","affiliation":[{"name":"Division of Neonatology Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Lista","sequence":"additional","affiliation":[{"name":"NICU \u201cV. 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