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BMD and body composition were measured three months after the initiation of Trikafta (study group) and compared to values obtained 2 years earlier. CF patients not treated with Trikafta, for whom BMD was measured 2 years apart, served as controls. Spirometry, lung clearance index (LCI), sweat test, six\u2010min\u00a0walk test (6MWT) and cardio\u2010pulmonary exercise test (CPET) were performed before and three months after the initiation of Trikafta.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine study patients, aged 18.6\u2009\u00b1\u20094.7 years, and nine controls. For the study group, BMI and hip and spine BMD increased significantly (19.4\u2009\u00b1\u20092.6 to 20.3\u2009\u00b1\u20092.19 BMI, <jats:italic>p<\/jats:italic>\u2009=\u20090.05; 0.73\u2009\u00b1\u20090.098 to 0.81\u2009\u00b1\u20090.12\u2009gr\/cm<jats:sup>2<\/jats:sup> hip, <jats:italic>p<\/jats:italic>\u2009=\u20090.017; 0.76\u2009\u00b1\u20090.14 to 0.82\u2009\u00b1\u20090.14\u2009gr\/cm<jats:sup>2<\/jats:sup> spine, <jats:italic>p<\/jats:italic>\u2009=\u20090.025). For the control group, there was no difference in hip or spine BMD. Lean body mass, %fat z\u2010score and fat mass\/height<jats:sup>2<\/jats:sup> z\u2010score increased significantly (34770.23\u2009\u00b1\u200910521.21 to 37430.16\u2009\u00b1\u200910330.09gr, <jats:italic>p<\/jats:italic>\u2009=\u20090.017; \u20130.8\u2009\u00b1\u20090.75 to 0.46\u2009\u00b1\u20090.58, <jats:italic>p<\/jats:italic>\u2009=\u20090.012; and \u22120.98\u2009\u00b1\u20090.66 to \u22120.04\u2009\u00b1\u20090.51, <jats:italic>p<\/jats:italic>\u2009=\u20090.025, respectively). 6MWT improved from 541.1\u2009\u00b1\u200948.9 to 592.9\u2009\u00b1\u200954.5\u2009m (<jats:italic>p<\/jats:italic>\u2009=\u20090.046). As expected, FEV1%pred increased (<jats:italic>p<\/jats:italic>\u2009=\u20090.008) and sweat chloride decreased significantly (<jats:italic>p<\/jats:italic>\u2009=\u20090.017). In CPET, VE\/VCO<jats:sub>2<\/jats:sub> improved, indicating better ventilatory efficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To the best of our knowledge, this is the first study evaluating the metabolic effects of Trikafta. The results are encouraging and offer hope beyond the well\u2010established effect on pulmonary disease. Larger long\u2010term studies are warranted to unpin the underlying physiological mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26243","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T04:48:15Z","timestamp":1668401295000},"page":"577-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Effect of Trikafta on bone density, body composition and exercise capacity in CF: A pilot study"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9874-7617","authenticated-orcid":false,"given":"Michal","family":"Gur","sequence":"first","affiliation":[{"name":"Pediatric Pulmonary Institute and CF Center, Rappaport Children's Hospital Rambam Health Care Campus  Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2013Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0055-5415","authenticated-orcid":false,"given":"Ronen","family":"Bar\u2013Yoseph","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Institute and CF Center, Rappaport Children's Hospital Rambam Health Care Campus  Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2013Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moneera","family":"Hanna","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Institute and CF Center, Rappaport Children's Hospital Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Abboud","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Institute and CF Center, Rappaport Children's Hospital Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohar","family":"Keidar","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine Technion\u2013Israel Institute of Technology  Haifa Israel"},{"name":"Nuclear Medicine Institute Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tala","family":"Palchan","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Institute Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazeed","family":"Toukan","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Institute and CF Center, Rappaport Children's Hospital Rambam Health Care Campus  Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2013Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Masarweh","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Institute and CF Center, Rappaport Children's Hospital Rambam Health Care Campus  Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2013Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irit","family":"Alisha","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Institute and CF Center, Rappaport Children's Hospital Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehama","family":"Zuckerman\u2010Levin","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine Technion\u2013Israel Institute of Technology  Haifa Israel"},{"name":"Pediatric Diabetes Unit, Rappaport Children's Hospital Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-166X","authenticated-orcid":false,"given":"Lea","family":"Bentur","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Institute and CF Center, Rappaport Children's Hospital Rambam Health Care Campus  Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2013Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1807120"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23240"},{"key":"e_1_2_9_4_1","unstructured":"FDA.FDA approves new breakthrough therapy for cystic fibrosis. 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