{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:27:39Z","timestamp":1779910059844,"version":"3.53.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["22ZDYF\u20102160"],"award-info":[{"award-number":["22ZDYF\u20102160"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to explore whether noninvasive high\u2010frequency oscillatory ventilation\u00a0(NHFOV) could reduce the incidence of reintubation compared with nasal intermittent positive pressure ventilation\u00a0(NIPPV) in the postextubation phase of preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomized controlled trials of NHFOV versus\u00a0NIPPV were searched in PubMed, EMBASE, Cochrane Central, and MEDLINE. Meta\u2010analysis was performed using Review Manager 5.3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four randomized controlled trials including 1138 preterm infants were included in this study. Compared with NIPPV, NHFOV reduced the incidence of reintubation in the post\u2010extubation phase of preterm infants (<jats:italic>p<\/jats:italic>\u2009=\u20090.01, RR\u2009=\u20090.72, 95% confidence interval (CI): 0.56\u223c0.94), and no heterogeneity was found in the four studies (<jats:italic>p<\/jats:italic>\u2009=\u20090.55, I<jats:sup>2<\/jats:sup>\u2009=\u20090%). In the sensitivity analysis, the result showed that there was no significant difference in the incidence of reintubation between NHFOV and NIPPV after excluding one study (<jats:italic>p<\/jats:italic>\u2009=\u20090. 05, RR\u2009=\u20090.76 95%\u00a0CI: 0.58\u223c1.00), and no heterogeneity was found in the other three studies (<jats:italic>p<\/jats:italic>\u2009=\u20090.95, I<jats:sup>2<\/jats:sup>\u2009=\u20090%). There was no statistical difference between NHFOV and NIPPV in BPD, air leak, IVH (\u2265Grade III) and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among mechanically ventilated preterm infants, compared with NIPPV, NHFOV was potentially beneficial to reduce the incidence of reintubation after extubation and did not increase the risk of complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26244","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T01:28:45Z","timestamp":1668389325000},"page":"704-711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Noninvasive high\u2010frequency oscillatory ventilation versus\u00a0nasal intermittent positive pressure ventilation for preterm infants as an extubation support: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"58","author":[{"given":"Kaixu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neonatology The Affiliated Women's and Children's Hospital, School of Medicine, UESTC  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neonatology The Affiliated Women's and Children's Hospital, School of Medicine, UESTC  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neonatology The Affiliated Women's and Children's Hospital, School of Medicine, UESTC  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5459-3727","authenticated-orcid":false,"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Women and Children's 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