{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:26:31Z","timestamp":1788909991885,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There have been conflicting reports on the relationship between asthma and COVID\u201019 severity. This study aimed to compare the risk of death among children with asthma and healthy peers hospitalized due to COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We carried out an analysis of all pediatric patients 2\u201319 years of age with asthma and COVID\u201019 registered in Influenza Epidemiological Surveillance Information System\u2010Gripe, a Brazilian nationwide surveillance database, between February 2020 and March 2022. The primary outcome was time to death, which was evaluated considering discharge as a competitive risk using the cumulative incidence function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 30,405 hospitalized children with COVID\u201019, 21,340 (70.2%) had no comorbidities, 6444 (21.2%) had comorbidities other than asthma, 2165 (7.1%) had asthma, and 465 (1.5%) had asthma with other comorbidities. The estimated probability of a fatal outcome for each group was 4.1%, 14.9%, 2.1%, and 10.7%, respectively. After adjustment, children with asthma had a 60% reduction in the hazard of death than healthy peers (hazard ratio [HR]\u2009=\u20090.39, 95% confidence interval [CI], 0.29\u20130.53, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Among children with asthma and no other comorbidities, two covariates were independently associated with in\u2010hospital mortality, age \u226512 years, HR\u2009=\u20094.0, 95% CI, 2.5\u20136.4), and low oxygen saturation at admission (HR\u2009=\u20092.3, 95% CI, 1.4\u20133.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children with asthma and no comorbidities had a lower risk of death compared with healthy peers after controlling for clinical and demographic confounding factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26245","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T09:04:50Z","timestamp":1668589490000},"page":"727-737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The association between pre\u2010existing asthma and reduced risk of death among children and adolescents hospitalized with COVID\u201019 in Brazil"],"prefix":"10.1002","volume":"58","author":[{"given":"Maria C. L.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Health Sciences Postgraduate Program, School of Medicine Federal University of Minas Gerais (UFMG) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico A.","family":"Colosimo","sequence":"additional","affiliation":[{"name":"Department of Statistics Federal University of Minas Gerais Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana A.","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Health Sciences Postgraduate Program, School of Medicine Federal University of Minas Gerais (UFMG) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herc\u00edlio","family":"Martelli\u2010J\u00fanior","sequence":"additional","affiliation":[{"name":"Health Science\/Primary Care Postgraduate Program State University of Montes Claros 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