{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:25:38Z","timestamp":1790101538283,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>INtubate\u2010SURfactant\u2010Extubate (InSurE) approach is traditional method of surfactant delivery in preterm neonates with respiratory distress syndrome (RDS).\u00a0Newer, less invasive surfactant administration (LISA) techniques lessen the need for mechanical ventilation and its adverse consequences. Evidence on the favorable effects of LISA can't be extrapolated from developed to developing countries. Aim of study is to compare the effectiveness of InSurE and LISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Primary outcome was to find need of intubation and mechanical ventilation within 72\u2009h of birth. Neonates were followed until discharge\/death for adverse events and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and\u00a0Methods<\/jats:title>\n                    <jats:p>Open\u2010label randomized controlled trial\u00a0(RCT) was conducted at tertiary neonatal intensive care unit. Preterm neonates with diagnosis of RDS were randomized in two groups (InSurE or LISA) to receive surfactant soon after birth. Nasal intermittent positive pressure ventilation (NIPPV) was used as primary mode of respiratory support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 150 neonates were analyzed (75 in each group). Insignificant statistical difference was seen in the need for intubation and mechanical ventilation within 72\u2009h of birth between the two groups (InSurE, 30 [40%] and LISA, 30 [40%], relative risk 1.0, 95% confidence interval 0.68\u20131.48). Twelve percent (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099, LISA group) and 14.6% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911 InSurE group) had adverse events during the procedure. Also, we observed insignificant statistical difference in the rates of major complications or duration of respiratory support, hospital stay, and mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LISA and InSurE are equally effectiSpontaneously breathing pretermve for surfactant administration in the treatment of RDS, when NIPPV is the primary mode of respiratory support. More RCTs are required to compare the efficacy and long\u2010term outcomes of LISA with InSurE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.26246","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T03:48:40Z","timestamp":1669175320000},"page":"738-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Surfactant administration in preterm babies (28\u201336 weeks) with respiratory distress syndrome: LISA versus InSurE, an open\u2010label randomized controlled trial"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3380-2259","authenticated-orcid":false,"given":"Aradhana","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Neonatology Government Medical College  Aurangabad Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amol","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Neonatology Government Medical College  Aurangabad Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Londhe","sequence":"additional","affiliation":[{"name":"Department of Neonatology Government Medical College  Aurangabad Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laxmikant","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Department of Neonatology Government Medical College  Aurangabad Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25545"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2019.03.226"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3443"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3848"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410203311603"},{"key":"e_1_2_11_7_1","unstructured":"Update of minimally invasive surfactant therapy [Internet]. 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