{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:23:25Z","timestamp":1780550605688,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Observational studies suggest that asthma\/wheezing improves after adenotonsillectomy (AT). However, there is a paucity of randomized clinical trial\u00a0(RCT) specifically studying the effects of AT in asthma\/wheezing. Therefore, we conducted a post\u2010hoc analysis of the Childhood Adenotonsillectomy Trial (CHAT), the largest RCT of AT in children with obstructive sleep apnea (OSA) to test the hypothesis that AT would result in fewer wheezing episodes.<\/jats:p><\/jats:sec>Methods<\/jats:title>In the CHAT study, 464 children with OSA, aged 5\u20139 years, were randomized to early AT (n<\/jats:italic>\u2009=\u2009226) or watchful waiting with supportive care (WWSC) (n<\/jats:italic>\u2009=\u2009227). For this post\u2010hoc analysis, children were categorized as having \u201cany wheezing\u201d versus \u201cno wheezing\u201d at baseline and at 7 months of follow\u2010up. A multivariate analysis was conducted to evaluate the association between \u201cany wheezing\u201d at follow\u2010up and treatment group after controlling for several potential confounders.<\/jats:p><\/jats:sec>Results<\/jats:title>Children in the \u201cany wheezing\u201d group were predominantly black, had more allergic rhinitis, eczema, second\u2010hand smoke exposure, body mass index, apnea\u2013hypopnea index (AHI), and had lower maternal education and family income than those in the \u201cno wheezing group.\u201d\u00a0In the AT arm, the prevalence of wheezing significantly decreased from baseline to follow\u2010up (at 7 months of the intervention) (47% vs. 21.6%, p<\/jats:italic>\u2009<\u20090.001); while in the WWSC arms did not change (45.2% vs. 43.1%, p<\/jats:italic>\u2009=\u20090.67). In the multivariate analysis, second\u2010hand smoke exposure, wheezing at baseline, and belong to WWSC arm (odds ratio: 3.65 [2.16\u20136.19]) increase the risk of wheezing at follow\u2010up.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study demonstrated that AT decreased the risk of wheezing at 7 months of follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26252","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T12:59:35Z","timestamp":1669726775000},"page":"772-777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of adenotonsillectomy with wheezing episodes in childhood: A secondary analysis of the Childhood Adenotonsillectomy Trial"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-4281","authenticated-orcid":false,"given":"Jose A.","family":"Castro\u2010Rodriguez","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology, School of Medicine Pontificia Universidad Catolica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3633-1851","authenticated-orcid":false,"given":"Fiorella","family":"Biancardi","sequence":"additional","affiliation":[{"name":"School of Medicine Pontificia Universidad Catolica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oslando","family":"Padilla","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Medicine Pontificia Universidad Catolica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea A.","family":"Beckhaus","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, School of Medicine Pontificia Universidad Catolica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1400-6852","authenticated-orcid":false,"given":"Ignacio E.","family":"Tapia","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Perelman School of Medicine at the University of Pennsylvania, Sleep Center, The Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2102"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21174"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2014.01.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2016.08.010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-015-0215-5"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2016.1220012"},{"key":"e_1_2_10_8_1","first-page":"212","article-title":"Does adenotonsillectomy affect the course of bronchial asthma and nasal allergy?","volume":"523","author":"Saito H","year":"1996","journal-title":"Acta Otolaryngol 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