{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:24:45Z","timestamp":1784100285634,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The natural evolution of obstructive sleep apnea (OSA) in young infants is not established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We re\u2010evaluated 10\u2010year pediatric sleep center infant polysomnography (PSG) data, excluding infants with syndromes, genetic defects, structural anomalies or periodic breathing\u2009&gt;\u20095% of sleep time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Obstructive events\u2009&gt;\u20091\u2009h<jats:sup>\u20101<\/jats:sup> were evident in 255 infants, of which 91 were eligible for the study. Of the 38 infants in a follow\u2010up study, 30 (79%) were male, 15 (40%) were born prematurely, 25 (66%) had observed apneas, and 13 (33%) had experienced a brief, unexplained event or had a sibling of the infant died suddenly. The first PSG was performed at a median corrected age of 4 weeks (interquartile range [IQR] 2\u22127) and the second at 11 weeks (IQR 9\u221214). The obstructive apnea and hypopnea index (OAHI) was greater in the supine compared to side\u2010sleeping position in both recordings (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), whereas OAHI dropped from 10\u2009h<jats:sup>\u20101<\/jats:sup> (IQR 6\u221224) in the first PSG to 3\u2009h<jats:sup>\u20101<\/jats:sup> (IQR 1\u22129) in the second PSG (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). OSA alleviation was also observable as a decrease in the number of oxygen desaturations (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), as a decrease in transcutaneous (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) and end\u2010tidal carbon dioxide (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) 95th percentile levels, and work of breathing (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). Seven infants had a third PSG to verify a satisfactory improvement of OSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OSA in young infants without a clear syndrome or structural anomaly is sleep position dependent and shows improvement during the following few months.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26255","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T06:19:10Z","timestamp":1669616350000},"page":"794-803","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Obstructive sleep apnea in young infants: Sleep position dependence and spontaneous improvement"],"prefix":"10.1002","volume":"58","author":[{"given":"Hanna\u2010Leena","family":"Kukkola","sequence":"first","affiliation":[{"name":"Department of Pediatrics New Children's Hospital Helsinki Finland"},{"name":"Pediatric Research Center, New Children's Hospital Helsinki University 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