{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:11:19Z","timestamp":1791576679991,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014684","name":"Scottish Cot Death Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001061","name":"Rebecca L. Cooper Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to investigate the frequency and severity of periodic breathing (PB) in clinically stable very preterm infants and identify infant and maternal factors associated with increased time spent and severity of PB in these infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Thirty\u2010eight infants (28\u201332 weeks gestational age) who were \u22653 days off noninvasive respiratory support, were studied for 2\u20133\u2009h with a daytime sleep study at 31\u201336 weeks postmenstrual age. Percent total sleep time spent in PB (%TSTPB) and time spent with SpO<jats:sub>2<\/jats:sub> &lt;90%, &lt;80%, and cerebral oxygenation &lt;55% during PB were calculated. Infant and maternal characteristics were correlated with %TSTPB and hypoxia during PB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of infants (92%) had at least one episode of PB and infants spent a median 9.1 [interquartile range: 1.2, 15.5] %TSTPB. 80%, 37%, and 37% of infants experienced SpO<jats:sub>2<\/jats:sub> &lt;90%, &lt;80% and cerebral oxygenation &lt;55%, respectively, during PB. Shorter duration of respiratory support, multigravida, multiparity, and maternal vitamin D deficiency were associated with higher %TSTPB. Multigravida, shorter duration on respiratory support, apnea of prematurity, and resuscitation at birth were associated with hypoxia during PB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of very preterm infants exhibited PB when they were off respiratory support and considered clinically stable. The time spent in PB was very variable between infants and was associated with significant hypoxia in some infants. Fewer days spent on respiratory support was associated with both increased frequency and severity of PB. However, the potential contribution of PB to neurocognitive outcomes remains uncertain and warrants further investigations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26273","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T11:39:00Z","timestamp":1670845140000},"page":"887-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Periodic breathing in clinically stable very preterm infants"],"prefix":"10.1002","volume":"58","author":[{"given":"Alicia K.","family":"Yee","sequence":"first","affiliation":[{"name":"Department of Paediatrics Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon S.","family":"Siriwardhana","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4944-7754","authenticated-orcid":false,"given":"Gillian M.","family":"Nixon","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Monash University  Melbourne Victoria Australia"},{"name":"Melbourne Children's Sleep Centre Monash Children's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora Y.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Monash University  Melbourne Victoria Australia"},{"name":"Monash Newborn, Monash Children's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3575-0461","authenticated-orcid":false,"given":"Rosemary S. 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