{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:42:42Z","timestamp":1775706162891,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["Clinical Fellowship award: BALDW16BO"],"award-info":[{"award-number":["Clinical Fellowship award: BALDW16BO"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cystic fibrosis (CF)\u2010related bone disease (CFBD) is seen in adults and can be associated with respiratory illness and malnutrition. There is limited and conflicting data regarding CFBD in pediatric CF. With longer life expectancy and promotion of disease prevention, pediatric CFBD demands further investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our center initiated a quality improvement (QI) project from April 2016 to December 2018 to improve CFBD screening in patients 8 years or older, per current CF Foundation (CFF) guidelines. Our team formulated a dual\u2010energy X\u2010ray absorptiometry\u00a0(DXA) scan algorithm based upon degree of bone mineral density (BMD); shared CFBD guideline recommendations in our quarterly newsletter; and ordered scans for eligible patients at weekly review meetings. We reviewed DXA results from 141 patients after institutional review board\u00a0approval and gathered data including comorbidities, genetics, anthropometric measures, medication exposure, and relevant serum studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three percent of our patients had normal BMD (<jats:italic>n<\/jats:italic>\u2009=\u200975). Seventeen patients (12%) had a <jats:italic>Z<\/jats:italic> score\u2009\u2264\u2009\u22122. Patients with lower BMD also had lower mean forced expiratory volume (FEV<jats:sub>1<\/jats:sub>) percent predicted (FEV<jats:sub>1<\/jats:sub>%) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) as well as lower body mass index\u00a0% (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Patients with lower BMD were overall older at time of DXA (<jats:italic>p<\/jats:italic>\u2009=\u20090.016). During study duration, 13 patients who had abnormal DXA results underwent repeat DXAs after physical therapy; 11 of the 13 showed improvement in DXA results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A DXA scan is a useful screening tool and can be used to identify pediatric patients who could benefit from further therapy and interventions to preserve adequate bone health and avoid further loss. QI initiatives can lead to improved screening and diagnosis and earlier intervention such as physical therapy. Further studies are needed to better understand the utility of physical therapy in children with CF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26304","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T02:14:03Z","timestamp":1672712043000},"page":"1136-1144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The use of DXA for early detection of pediatric cystic fibrosis\u2010related bone disease"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4981-9749","authenticated-orcid":false,"given":"Christina","family":"Chadwick","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renallie","family":"Arcinas","sequence":"additional","affiliation":[{"name":"Children's Health Rehabilitation and Therapy Services Physical Rehabilitation, Children's Health  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Ham","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology UT Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Research Administration, Children's Health  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacie","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Pediatric Clinical Nutrition Clinical Nutrition, Children's Health  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megha","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preeti","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prigi Anu","family":"Varghese","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelli","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Pulmonology Children's Health  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Troendle","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7088-8530","authenticated-orcid":false,"given":"Meghana","family":"Sathe","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2016.01.009"},{"key":"e_1_2_9_3_1","volume-title":"Bone Disease in CF Clinical Care Guidelines","author":"Rayas MS","year":"2005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.08.017"},{"key":"e_1_2_9_5_1","unstructured":"Cystic Fibrosis Foundation.\u00a0Cystic Fibrosis Foundation Patient Registry. 2011 Annual Data Report; 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