{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:15:07Z","timestamp":1740104107663,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There are no precise data about the effect of <jats:italic>Aspergillus<\/jats:italic> infection on lung function other than allergic bronchopulmonary aspergillosis (ABPA) in patients with cystic fibrosis (pwCF). Here, we aimed to determine clinical phenotypes caused by <jats:italic>Aspergillus<\/jats:italic> spp. using laboratory and immunologic parameters and to compare <jats:italic>Aspergillus<\/jats:italic> phenotypes in terms of pulmonary function tests (PFT) prospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010three pwCF who had <jats:italic>Aspergillus<\/jats:italic> isolation from respiratory cultures in the last year (case group) and 20 pwCF without <jats:italic>Aspergillus<\/jats:italic> isolation in sputum (control group) were included. <jats:italic>Aspergillus<\/jats:italic> immunoglobulin (Ig)\u2010G, <jats:italic>Aspergillus<\/jats:italic> IgE, <jats:italic>Aspergillus<\/jats:italic> polymerase chain reaction\u00a0(PCR), galactomannan, total IgE from blood samples, and <jats:italic>Aspergillus<\/jats:italic> PCR and galactomannan from sputum, and skin prick test reactivity to <jats:italic>Aspergillus<\/jats:italic> antigen were used to distinguish different <jats:italic>Aspergillus<\/jats:italic> phenotypes. Pulmonary functions and frequency of pulmonary exacerbations were evaluated during a 1\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 23 pwCF, 11 (47.8%) had <jats:italic>Aspergillus<\/jats:italic> colonization, nine (39.1%) had <jats:italic>Aspergillus<\/jats:italic> bronchitis, and three (13%) had ABPA. <jats:italic>Aspergillus<\/jats:italic> infection was not associated with worse <jats:italic>z<\/jats:italic>\u2010scores of forced expiratory volume in the first second (FEV1) (<jats:italic>p<\/jats:italic>\u2009=\u20090.612), forced vital capacity \u00a0(<jats:italic>p<\/jats:italic>\u2009=\u20090.939), and the median FEV 1% decline (0.0%\/year vs. \u22124.7%\/year, <jats:italic>p<\/jats:italic>\u2009=\u20090.626). The frequency of pulmonary exacerbations in the <jats:italic>Aspergillus<\/jats:italic> infected and noninfected groups was similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although <jats:italic>Aspergillus<\/jats:italic> spp. Isolation in pwCF was not associated with decreased lung function, a further decline was seen in the ABPA subgroup, and frequent pulmonary exacerbations during the 1\u2010year follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26319","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T08:26:05Z","timestamp":1674030365000},"page":"1185-1193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case\u2010control study of the effects of <i>Aspergillus<\/i> clinical phenotypes on pulmonary functions in patients with cystic fibrosis"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6909-7993","authenticated-orcid":false,"given":"Halime","family":"Nayir Buyuksahin","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pulmonology Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9931-9473","authenticated-orcid":false,"given":"Deniz","family":"Dogru","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pulmonology Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1405-8401","authenticated-orcid":false,"given":"Nagehan","family":"Emiralioglu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pulmonology Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0334-6336","authenticated-orcid":false,"given":"Dilber","family":"Ademhan Tural","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pulmonology Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0052-8361","authenticated-orcid":false,"given":"Beste","family":"\u00d6zsezen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pulmonology Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birce","family":"Sunman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pulmonology Hacettepe University Faculty of Medicine Ankara 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